New method detects chemically modified base molecules and amino acids representing a substantive step toward realizing personalized genomic diagnosis of cancer and other diseases.
Tumor Markers - For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results.
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results.
‘New method detects chemically modified base molecules and amino acids representing a substantive step toward realizing personalized genomic diagnosis of cancer and other diseases.’
"Personalized medicine applications require a method that does not involve chemical modification using expensive reagents and protracted polymerase chain reaction (PCR) amplification, to allow high throughput at low cost," explains Takahito Ohshiro, the first author of a new Osaka University study. In the study, the team led by Masateru Taniguchi used current-tunneling measurements to record the single-molecule conductances of the base molecules. The tunneling currents flowing through single molecule were measured by gold electrodes - separated 0.75 nm apart from each other, equivalent to the size of a DNA base molecule - using a mechanically controllable break-junction. Single-molecule signals were then obtained in forms of current spikes, whose height represents the electron transport through a molecule.
The team successfully determined the entire base sequences - without having to chemically modify DNA or amplify it by PCR - of four types of DNA corresponding to the let-7 microRNA, a 22-base cancer marker. In addition, they could count the numbers of molecules in a solution to determine the abundance ratios of two DNA strands that differ by a single base sequence. The study was published in Scientific Reports.
Clinical Utility of Personalized Medicine Program for Cancer Patients
A personalized cancer therapy program using an integrated genomic approach has been developed and tested by scientists from the Icahn School of Medicine.
A personalized cancer therapy program using an integrated genomic approach has been developed and tested by scientists from the Icahn School of Medicine.
Source-Eurekalert
Advancing Personalized Medicine from Space to Earth: NASA
The Twins Study is NASA's first step to establish a foundation and methodology to integrate space-related omics with traditional scientific activities.
The Twins Study is NASA's first step to establish a foundation and methodology to integrate space-related omics with traditional scientific activities.
New Powerful Tool May Help Bring Personalized Medicine Closer
One of the biggest obstacles in successfully treating metabolic disorders such as diabetes, obesity etc, is the variation in the way patients respond to medication.
One of the biggest obstacles in successfully treating metabolic disorders such as diabetes, obesity etc, is the variation in the way patients respond to medication.
