Fruit Flies Avoid Foods Rich in Calcium

Calcium is an essential element. Calcium taste not only exists in humans and animals, but also exists in fruit flies like Drosophila melanogaster.

Calcium is an essential element, whether too much or too little can affect the health of humans and animals. However, calcium taste was also found to exist in fruit flies, reveals a new study.

Sensing calcium at all can be crucial. Though //it doesn't fit into the five established tastes the tongue's receptors can identify sweet, sour, salty, bitter and savory (umami) humans can taste it, and describe it as slightly bitter and sour.

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‘Fruit flies have great aversion to foods that are high in calcium. However, they are indifferent to foods that are low in calcium.’

New research conducted by scientists at UC Santa Barbara and colleagues in Korea has established that calcium taste also exists in fruit flies (Drosophila melanogaster).

The team also uncovered a unique class of Gustatory receptor neurons (GRNs) necessary for calcium taste in these model organisms.

Surprisingly, given that some calcium is necessary to sustain life, the flies were indifferent to low calcium and averse to high levels. The findings appear in the journal Neuron.

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"We wanted to understand the underlying mechanisms used to respond to the presence of calcium in food," said senior author Craig Montell, UCSB's Duggan Professor of Molecular, Cellular, and Developmental Biology and Neuroscience.

"We not only identified the taste neurons but also found three receptor proteins that are important in sensing calcium. In fact, eliminating any one of them allowed us to do an interesting survival experiment."

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The investigators used petri dishes with one side containing solely sugar (fructose) and the other a mix of sugar and a high level of calcium.

Normal flies that rejected the high-calcium side and ate only pure fructose survived. Mutant flies those in which any one of the three newly found GRNs was removed were unable to distinguish the two halves of the petri dish. As a result, they consumed enough of the calcium to cause viability problems and, over time, died.

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"It turns out that fruit flies don't have a mechanism for sensing low calcium even though it's good for them, but they are trying to guard against consuming too much calcium," Montell explained.

"Surprisingly, we found that calcium avoidance occurred through two mechanisms: activation of a unique class of GRNs, distinct from those that sense bitter compounds and which cause a stop-feeding signal when activated. In addition, calcium inhibits sugar-activated GRNs," he added.

"In humans, high calcium is associated with many diseases and can even be life threatening. Our results suggest that calcium taste might function primarily as a deterrent in wide range of animals, including humans."

Source-Eurekalert