Gene Behind Rheumatoid Arthritis

Study links defective gene with rheumatoid arthritis (RA).

In their study, researchers from VIB (Flanders Institute for Biotechnology) and Ghent University demonstrated that a cell-specific defect in the expression of the A20 gene could contribute to the development of rheumatoid arthritis in mice, thereby identifying A20 as a possible target for the generation of new drugs.

A20 is a protein, which plays a key role in the generation of the inflammatory response.

VIB researchers led by Geert van Loo and Rudi Beyaert at Ghent University have developed mice with myeloid cells incapable of producing A20.

In collaboration with Dirk Elewaut, rheumatologist at Ghent University Hospital (Ghent University), who co-supervised the research, they found that these mice had elevated levels of pro-inflammatory cytokines in their blood and joints, and spontaneously developed RA with severe inflammation and osteoporosis.

What is arthritis?
The pain in the joints can be effectively eased through the practice of yoga, which gives flexibility to the joints and strength to the muscles of the body parts

Interestingly, the arthritis in this mouse model was not dependent on TNF, a cytokine that normally plays an essential role in many inflammatory diseases including RA.

The study confirms the crucial role of A20 in the control of inflammatory responses and shows that a defect in A20 in myeloid cells can give rise to RA that is not responsive to anti-TNF treatment.

New Study Says Use of Placebo in Rheumatoid Arthritis Clinical Trials may Negatively Impact Patients
The debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage has been re-opened

From a therapeutic perspective, this is a very important finding, since anti-TNF therapy fails in 30 percent of RA patients.

The study has been published in Nature Genetics.

Rheumatoid Arthritis Patients Don't Receive Statins After Heart Attack
Around 20% of rheumatoid arthritis patients are not receiving the recommended therapies, such as statins and betablockers, following a first heart attack.

Source-ANI