Researchers at Massachusetts General Hospital (MGH) have come a step closer to using gene therapy for Huntington disease.
Researchers at Massachusetts General Hospital (MGH) have come a step closer to using gene therapy for Huntington disease.
The team led by Kelvin J. A. Davies, professor of gerontology in the USC Davis School of Gerontology and professor of biological sciences in the USC College of Letters, Arts and Sciences has found that a form of the gene RCAN1, known as RCAN1-1L, is dramatically decreased in human brains affected by Huntington disease.
New Therapeutic Strategy Could Target Toxic Protein in Huntington's Disease
Howard Hughes Medical Institute researchers have designed tiny RNA molecules that shut off the gene that causes Huntington's disease without damaging that gene's healthy counterpart,
Howard Hughes Medical Institute researchers have designed tiny RNA molecules that shut off the gene that causes Huntington's disease without damaging that gene's healthy counterpart,
The investigators also showed that increasing levels of RCAN1-1L rescues cells from the toxic effects of Huntington disease, a result that could someday lead to new avenues of treatment.
"Our discovery offers real hope and may even have wide-ranging implications for a variety of other important CAG repeat-related diseases," Davies said.
Physical Exercise Could Delay Onset of Huntington's Disease
A new study on mice has found that the simple act of running in an exercise wheel may delay the onset of some symptoms of Huntington's disease.
A new study on mice has found that the simple act of running in an exercise wheel may delay the onset of some symptoms of Huntington's disease.
"Further proof of protection by RCAN1-1L will be required in-vivo, or in actual Huntington disease patients," Ermak added.
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Mutant Protein in Huntington's Disease may Be Destroyed by New Tool
Researchers from Emory University have announced the development of an 'intrabody' tool that may help in wiping off the clusters of the mutant protein responsible for neurodegeneration
Researchers from Emory University have announced the development of an 'intrabody' tool that may help in wiping off the clusters of the mutant protein responsible for neurodegeneration
Source-ANI
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Damage to D1 Neurons too Could Lead to Huntington’s Disease
Australian researchers have found that damage to D1 neurons too could lead to the Huntington’s disease. Thus far the focus had been on D2 neurons only.
Australian researchers have found that damage to D1 neurons too could lead to the Huntington’s disease. Thus far the focus had been on D2 neurons only.
