Scientists have successfully used viral vectors to deliver genetic material to kidney cells.
Prevention of Kidney Disease - Causes & Prevention
Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and blood pressure under check, and regular tests can help prevent it.
Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and blood pressure under check, and regular tests can help prevent it.
‘Scientists have successfully used viral vectors to deliver genetic material to kidney cells.’
Almost 50 years after it was first proposed, gene therapy is now entering into regular clinical use. The most common method uses adeno-associated virus (AAV) to deliver genetic material to target cells, but no AAV has been capable of doing so in the kidney. Of 6 AAVs tested, a synthetic AAV called Anc80 showed specific and high efficiency for transducing different kidney cell types in both mice and humans. Anc880 was also successfully used in gene therapy strategies to treat mice with kidney scarring.
The findings may be useful in therapeutic approaches to treat CKD, a condition that affects10% of the population worldwide. "CKD is an enormous problem and there has been little innovation and no significant therapies in decades. Our discovery shows that genetic material can be delivered to kidney cells that play a key role in CKD," said Dr. Humphreys. "Future gene therapy approaches could deliver genes that slow or reverse the growth of these cells in CKD."
Quiz on Kidney Stones
Kidney stones or calculus produces the most severe form of pain in humans. The pain has often been described to be worse than childbirth, broken bones, gunshot wounds, burns, or surgery. Once you form a kidney stone you are always susceptible to another stone. Take this quiz to find out how much do you know about stone disease. Once you complete find out how you fared compared to others who have taken the quiz.
Kidney stones or calculus produces the most severe form of pain in humans. The pain has often been described to be worse than childbirth, broken bones, gunshot wounds, burns, or surgery. Once you form a kidney stone you are always susceptible to another stone. Take this quiz to find out how much do you know about stone disease. Once you complete find out how you fared compared to others who have taken the quiz.
Pyeloplasty of Kidney
Animation showing Pyeloplasty surgical operation to relieve obstruction of the pelvi-ureteric junction of the kidney.
Animation showing Pyeloplasty surgical operation to relieve obstruction of the pelvi-ureteric junction of the kidney.
New Meta-analysis Aims to Improve Outcomes in Patients With Severe Chronic Kidney Disease (CKD G4)
New meta-analysis conducted recently enables better prediction of risk of adverse events in patients with severe chronic kidney disease (CKD G4) and improve patient outcomes.
New meta-analysis conducted recently enables better prediction of risk of adverse events in patients with severe chronic kidney disease (CKD G4) and improve patient outcomes.
