Genetics was found to help predict the effectiveness of tolvaptan in autosomal dominant polycystic kidney disease.
Promising Treatment for an Incurable, Deadly Polycystic Kidney Disease Being Developed
New drug which is in early clinical trials has shown promising results in treating polycystic kidney disease, a genetic disorder that causes the kidneys to swell with many cysts and eventually lead to organ failure.
New drug which is in early clinical trials has shown promising results in treating polycystic kidney disease, a genetic disorder that causes the kidneys to swell with many cysts and eventually lead to organ failure.
‘Genetics helps predict the effectiveness of tolvaptan in autosomal dominant polycystic kidney disease.’
Methods: We retrospectively evaluated the relationship between genotype and the efficacy of tolvaptan in 18 patients with ADPKD who had been treated at Toranomon Hospital and undergone genetic testing between April 2016 and February 2020. Results: The annual change in estimated glomerular filtration rate (ΔeGFR/y) from before to after tolvaptan was from a median of −5.5 to −2.5 mL/min/1.73 m2 in the PKD1 truncating group, −3.3 to −2.4 mL/min/1.73 m2 in the PKD1 non-truncating group, −3.1 to −1.6 mL/min/1.73 m2 in the PKD2 group, and −1.9 to −2.6 mL/min/1.73 m2 in the group with no PKD1/2 mutation. The median degrees of improvement of ΔeGFR/y were 2.5 (45%), 0.4 (10%), 0.6 (28%), and −0.7 (−37%) mL/min/1.73 m2, respectively. Compared with the group of patients with any PKD1/2 mutation, the group with no PKD1/2 mutation showed significantly less improvement in ΔeGFR/y with tolvaptan (0.6 vs. −0.7 mL/min/1.73 m2, respectively; p = 0.01) and significantly less improvement in the annual rate of increase in total kidney volume (TKV) with tolvaptan (−6.7 vs. −1.1%, respectively; p = 0.02).
Source-Medindia
Screening for Brain Aneurysms in Polycystic Kidney Disease Patients
Among polycystic kidney disease patients who had evidence of aneurysms at the initial screening, new brain aneurysms were detected in 5 patients during an average follow-up of 8 years, and none of the aneurysms ruptured.
Among polycystic kidney disease patients who had evidence of aneurysms at the initial screening, new brain aneurysms were detected in 5 patients during an average follow-up of 8 years, and none of the aneurysms ruptured.
Quiz on Kidney
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
kidneys remove wastes and extra fluid from your body. Kidneys also remove acid that is produced by the cells of your body and maintain a healthy balance of water, salts, and minerals-such as sodium, calcium, phosphorus and potassium-in your blood ().
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
Kidneys also make hormones that help
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
kidneys remove wastes and extra fluid from your body. Kidneys also remove acid that is produced by the cells of your body and maintain a healthy balance of water, salts, and minerals-such as sodium, calcium, phosphorus and potassium-in your blood ().
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
Kidneys also make hormones that help
- Control your blood pressure
- Make red blood cells
- Keep your bones strong and healthy
