Genes Linked to Anxiety are also Linked to Depression

Genes that are responsible for anxiety, worry and low mood also cause depression. Identifying these genes can help improve diagnosis and treatment.

Genes that are linked to anxiety, worry and low mood are the one's that cause depression. Understanding the mechanisms of these genes can help improve diagnosis and treatment, reveals a new study.

The study, DNA analysis of over 300,000 //people, revealed 116 gene variations linked to neuroticism characterized by feelings of anxiety, worry and guilt.

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‘Many genes that are linked to neuroticism cause anxiety, worry and guilt are also responsible for causing depression.’

The same genes associated with neuroticism had some overlap with genes linked to a susceptibility to depression and some other psychiatric conditions.

More than half of the genetic variations associated with neuroticism are expressed in the brain, the researchers said.

"For millennia it has been recognized that people have a greater or lesser tendency to feel low, worry, and experience other negative emotions. We knew that a part of the explanation is genetic differences between people, but it's been a mystery which genes are involved," said Michelle Luciano, from the University of Edinburgh.

Neuroticism can Trigger Anxiety and Depression Disorders in Young People
Young people who are high on the personality trait of neuroticism are highly likely to develop both anxiety and depression disorders.

"These new results make a substantial contribution to solving that mystery by pointing to many specific places in the genome that are linked with neuroticism," Luciano added.

For the study, published in the journal Nature Genetics, the team analysed genetic information from a group of people aged from 39 to 73, whose levels of neuroticism had been measured by a personality questionnaire.

Neurotic Behavior Linked To Reduced Risk of Mortality
Those who have higher levels of the personality disorder called neuroticism were at lower risk of mortality but the reason remains unknown.

The results promise paths to understand the mechanisms whereby some people become depressed, and of broader human differences in happiness. They are a resource for those seeking treatments for depression, the researchers said.

Genes and Human Behavior Share a Strong Link
Our genes is one important factor that plays a crucial role in determining the way we feel; be it happy or depressed.

Source-IANS