Researchers at the Institute of Cancer Research have identified the genetic mutation responsible for developing leukemia in children.
It was found that the gene linked with leukemia ETV6-RUNX1 that was generated in the womb was similar in both the pairs of twins. There were 22 similar gene mutations in both pairs, which were not significant in development of leukemia.
A mutation, called NF1, appeared in one pair of twins. This gene was inherited from their parents. The mutation predisposed the twins to neurofibromatosis, a condition that is considered a risk factor for leukemia.
The findings are published in the journal Proceedings of the National Academy of Sciences.
Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
Immunotherapy Showed Promising Antileukemia Activity in Pediatric Patients: Research
Researchers using patients' own immune cells in an immunotherapy approach achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant.
Researchers using patients' own immune cells in an immunotherapy approach achieved responses in children whose acute lymphocytic leukemia (ALL) had returned after a bone marrow transplant.
