Why some genes go out of control is being explained in a new discovery that scientists are examining.
Scientists Identify Protein That Stimulates Production of T-cells
Canadian and Finnish researchers have identified a protein called Wnt4, which can stimulate the production of T-cells, the white blood cells that recognise and kill infectious agents.
Canadian and Finnish researchers have identified a protein called Wnt4, which can stimulate the production of T-cells, the white blood cells that recognise and kill infectious agents.
Because this pathway exists in humans and is involved in many conditions such as cancer, severe immune deficiencies, autoimmune diseases, and allergies. This discovery reveals a new and potentially important drug target for these conditions.
"We hope that our study will open new horizons for researchers studying mammalian JAK/STAT signaling which eventually leads to better understanding how mammalian JAK/STAT signaling is regulated," said Mika Rdmet, Ph.D., co-author of the study from the Institute of Medical Technology at the University of Tampere in Finland.
Nutrients That may Support Immune Health Decreased in Americans With Phytonutrient Gap
A new report says that a majority of Americans report getting a cold or flu in the past year and a third say they'll make lifestyle changes to prevent getting sick again this year.
A new report says that a majority of Americans report getting a cold or flu in the past year and a third say they'll make lifestyle changes to prevent getting sick again this year.
To make this discovery, Rdmet and colleagues "silenced" all of the fruit fly genes one by one using RNAi-based screening methods in cultured Drosophila (fruit fly) cells and then analyzed which genes were important for JAK/STAT signaling.
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Bare Essentials Used by Immune System to Speedily Detect Drug Targets
A less-is-more approach to designing effective drug treatments that are precisely tailored to disease-causing pathogens has been taken by scientists at Johns Hopkins.
A less-is-more approach to designing effective drug treatments that are precisely tailored to disease-causing pathogens has been taken by scientists at Johns Hopkins.
Further research showed that suppression of eye transformer expression in the eyes of fruit flies by in vivo RNAi causes hyper-activation of JAK/STAT signaling indicated by drastic eye overgrowth when JAK/STAT signaling was activated.
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Cells Which Protect Against Immune System Attack Discovered
Scientists have discovered a novel type of cell in mice which suppresses the immune system, protecting the animal's own cells from immune system attack.
Scientists have discovered a novel type of cell in mice which suppresses the immune system, protecting the animal's own cells from immune system attack.
Source-ANI
