Tumor DNA sequencing provides a more effective way to predict a patient’s risk of kidney cancer recurrence, stated researchers.
Renal Cell Carcinoma-Causes-Risk Factors-Symptoms-Diagnosis-Treatment-Prevention
Renal cell carcinoma is kidney cancer that affects the lining of the kidney tubules. The initial stages of the cancer are asymptomatic and this makes early management of the disease difficult.
Renal cell carcinoma is kidney cancer that affects the lining of the kidney tubules. The initial stages of the cancer are asymptomatic and this makes early management of the disease difficult.
‘Kidney cancer recurrence can be better predicted using DNA sequencing. Globally, more than 400,000 people are diagnosed with kidney cancer each year.’
The findings may be used to develop more personalized treatment approaches for kidney cancer in the future. Co-lead investigator Dr. Naveen Vasudev, Associate Professor and Honorary Consultant in Medical Oncology in the Leeds Institute of Medical Research at St James’s, said: “Development of new treatment for kidney cancer has lagged behind other cancers and we largely continue to adopt a ‘one size fits all’ approach.
“Accurately determining the risk of recurrence is very important. As well as helping us identify how often patients need to be seen by their doctors, it helps us to decide who to treat with immunotherapy. This treatment has recently been shown to reduce the chances of the cancer coming back but can cause side-effects. The danger currently is that some patients may be over-treated, so being able to better identify patients at low risk of recurrence is important since they could be spared more treatment.”
Quiz on Kidney
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
![Healthy Foods for People with Kidney Disease]( "Healthy Foods for People with Kidney Disease")
kidneys remove wastes and extra fluid from your body. Kidneys also remove acid that is produced by the cells of your body and maintain a healthy balance of water, salts, and minerals-such as sodium, calcium, phosphorus and potassium-in your blood ().
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
![Lifetime Risk Calculator for Cancers]( "Lifetime Risk Calculator for Cancers")
Kidneys also make hormones that help
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
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Healthy Foods for People with Kidney Disease
For people with kidney disease, the choice of foods becomes limited. Here’s a list of healthy foods that promote kidney health.
For people with kidney disease, the choice of foods becomes limited. Here’s a list of healthy foods that promote kidney health.
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
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Lifetime Risk Calculator for Cancers
What are your chances for developing some common cancers in your lifetime - find out now.
What are your chances for developing some common cancers in your lifetime - find out now.
- Control your blood pressure
- Make red blood cells
- Keep your bones strong and healthy
The researchers found some 91% of patients in one mutation group remained disease-free five years after surgery, meaning patients in this group may potentially avoid unnecessary treatment. Meanwhile, the percentage of patients in a different mutation group who remained disease-free at five years was much lower, at 51%. This identified them as requiring more aggressive treatment.
Preventing Kidney Cancer Recurrence
Currently, doctors assess the risk of kidney cancer returning by looking at features like the size of the tumor and how aggressive it appears under a microscope. With up to 30% of localized kidney cancers returning after surgery, more accurate methods of assessing this risk are needed, meaning patients who do not need further treatment can be spared it.Dr. Vasudev said: “Genomics - the study of genes and how they interact with each other – is a key area of development in patient care for the NHS. Here we show how genomics might be applied to patients with kidney cancer, potentially creating more personalized treatment options for thousands of patients each year.”
Co-lead investigator Dr. Yasser Riazalhosseini, Assistant Professor of Human Genetics, and Head of Cancer Genomics at Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University, said: “Our research shows that it may be possible to improve the way we determine risk in each patient by looking at the genetic mutations present in their cancer. DNA sequencing is already being used to help patients with other types of cancer and so could be readily applied to patients with kidney cancer.”
Source-Eurekalert
