Unique microbes in the gut could help fight against infectious agents and reduce the chances of inflammatory conditions. Centenarians carry these kinds of good microbes in higher numbers, found a study.
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‘Odoribacteraceae is a family of good bacteria present in the gut. They are capable of producing a unique bile acid that helps fight against gastrointestinal pathogens.’
The study has been published in the journal Nature . What Forms The Unique Gut Microbiome Of Centenarians?
To understand how centenarians display decreased susceptibility to aging-associated illness and other infectious diseases, the research team analyzed the stool samples from three groups of Japanese people:
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• Elderly individuals (aged between 85 and 89 years old)
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On experimenting, they found that centenarians had microbes from the family Odoribacteraceae, which are capable of producing Isoallo-lithocholic acid compared with elderly and young individuals.
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How Could These Bacteria Promote Longevity?
The unique bile acid produced by the bacterial family has potent antimicrobial effects against many infectious bacteria, especially Clostridioides diffcile and Enterococcus faecium .
Clostridioides difficile causes unpleasant, serious bowel problems, including diarrhea, says the National Health Service. Also, a 2020 study showed that the bacterium Enterococcus faecium has an 'inherent quality to build resistance to antibiotics that allow it to thrive in hospital environments.' It is associated with infections of the urinary tract and bloodstream.
The team suggests that these antibacterial effects of the centenarian gut microbiome could be one of the reasons behind their longevity.
"Our findings show an association between Odoribacteriaceae and centenarians. Although it might suggest that these bile-acid-producing bacteria may contribute to longer lifespans, we do not have any data showing the cause and effect relationship between them," concluded Professor Honda, co-investigator of the study.
Source-Medindia
