Gut Microbiota Linked to Alcoholic Liver Disease

A potential role in the development of alcoholic liver disease (ALD) may be played by gut microbiota as per reviews in the exciting new data

A potential role in the development of alcoholic liver disease (ALD) may be played by gut microbiota as per reviews in the exciting new data. Though an early stage animal model, the French study highlights the possibility of preventing ALD with faecal microbiota transplantation – the engrafting of new microbiota, usually through administering human faecal material from a healthy donor into the colon of a recipient.2

In the study, two groups of germ-free mice received gut microbiota transplants from human representatives; one set from a patient with severe alcoholic hepatitis, the other from a patient with a history of alcohol abuse butwithout alcoholic hepatitis. The two sets of germ-free mice were then fed a liquid alcoholic diet.

New Prediction Model may Improve Patient Survival Following Paracetamol-related Liver Failure
A high mortality rate has been noted in the UK paracetamol toxicity which is the most common cause of ALF.

The group that received microbiota from the patient with severe alcoholic hepatitis developed a more severeliver injury and a higher disruption of the intestinal mucosa in direct comparison to the group that received microbiota from the patient without severe alcoholic hepatitis. The study also identified two Clostridium bacteria that were able to produce ethanol in vitro and that were systematically associated with intestinal microbiota associated liver injury.

EASL Scientific Committee Member Prof. Frank Lammert commented: "Among heavy drinkers, the severity of alcoholic liver disease does not strictly correlate with the amount of alcohol intake, meaning that other factors must be influencing its development."

"These findings provide first evidence for a causal role of gut microbiota in alcohol-induced inflammation, and open up new avenues for the treatment of alcoholic liver disease with potentially better patient outcomes."At present, intestinal microbiota is considered to constitute a "microbial organ": one that has pivotal roles in the body's metabolism as well as immune function. Therefore transplantation aims to restore gut functionality and re-establish the homoestasis of intestinal flora.

Non Alcoholic Fatty Liver Disease an Independent Cardiovascular Risk Factor
More evidences have now been provided to clarify the role of non alcoholic fatty liver disease as an independent risk factor for the development of cardiovascular disease (CVD)

The study was developed by an INRA-Micalis and INSERM/Paris-South University/Antoine-Béclère hospitalcollaboration.
Source-Eurekalert

Scientists Explore Link Between Low Vitamin D Levels and Fatty Liver Disease
In British children, an association between low vitamin D status and non-alcoholic fatty liver disease (NAFLD) has been discovered by scientists.