![Gut Microbiota may Boost Efficacy of Cancer Immunotherapies Gut Microbiota may Boost Efficacy of Cancer Immunotherapies](https://images.medindia.net/health-images/1200_1000/polycystic-ovarian-syndrome-and-gut-microbiome.jpg)
‘The effectiveness of adoptive T cell therapy (ACT) in mice with cancer is significantly affected by differences in the natural makeup of gut bacteria and treatment with antibiotics.’
![pinterest](https://images.medindia.net/icons/news/social/pinterest.png)
Experiments performed by coauthor Mireia Uribe-Herranz, PhD, a research associate in Facciabene's lab, demonstrate that when ACT was performed on genetically identical animals obtained from different vendors (Jackson Laboratory or Harlan Laboratories), which carry different microbiota, impact of the therapy was not identical. Animals obtained from Harlan showed a much stronger anti-tumor effect compared to animals from Jackson. ![twitter](https://images.medindia.net/icons/news/social/twitter.png)
![facebook](https://images.medindia.net/icons/news/social/facebook.png)
![whatsapp](https://images.medindia.net/icons/news/social/whatsapp.png)
![linkedin](https://images.medindia.net/icons/news/social/linkedin.png)
![pinterest](https://images.medindia.net/icons/news/social/pinterest.png)
Depletion of gram-positive bacteria within the gut, using an antibiotic called vancomycin, also increased the efficacy of the therapy, improving the anti-tumor response and overall remission rate in less-responsive mice. The beneficial responses were associated with an increase in systemic dendritic cells, which in turn increased the expression of interleukin 12 (IL-12), which sustained expansion and anti-tumor effects of transferred T cells.
To define a relationship between gut bacteria and the efficacy of ACT, the researchers transplanted fecal microbiota from Jackson mice to Harlan mice. They found that Harlan mice transplanted with Jackson microbiota copied the anti-tumor response and tumor growth of Jackson mice.
"This means that the microbiota-dependent response to ACT was successfully transferred between mice, and that modulation with specific antibiotics can be used to increase ACT efficacy," Facciabene said, confirming that this technique could be applied to control gut microbiome populations and improve ACT. Collectively, the findings demonstrate an important role played by the gut microbiota in the antitumor effectiveness of ACT.
Advertisement