A newly identified compound, FR900359 (FR), from coralberry leaves inhibit G protein and prevent broncho-constriction in asthmatic mouse.
Highlights:
A new active compound with pharmaceutical property was extracted from coralberry leaves to fight asthmatic lung disease. The compound with cryptic name FR900359 (FR) completely inhibited airway constriction characteristic of asthma. Ardisia crenata, commonly called coralberry is native to East Asia and for the most part has been disregarded by science--until now. The research was conducted at the University of Bonn and has been published in the journal Science Translational Medicine.- Compound from coralberry leaves called FR900359 (FR) proved to prevent bronchial muscle contraction in rat, pig and human cells ex-vivo and asthmatic rat models in-vivo.
- FR’s mechanism of action is similar to currently available drugs, which inhibit G protein activity.
- FR selectively inhibits Gq protein which suggested to be a useful therapeutic for broncho-constriction in asthmatic lung disease.
Asthma - Factors, Common Allergens, Diagnosis, Treatment, Support Groups, FAQs
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways that result in coughing, wheezing or breathlessness. Allergy and other airway irritants can trigger it
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways that result in coughing, wheezing or breathlessness. Allergy and other airway irritants can trigger it
‘A novel compound called FR900359 (FR), from coralberry leaves have been found more efficient in treating asthmatic symptoms, which also has prolonged action compared to commonly used drug salbutamol.’
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Significance of the Study
People with asthma regularly suffer from airway constriction preventing adequate ventilation of the lungs. The constriction is a result of bronchial muscle contraction in these patients. This results in shortness of breath, that may become life threatening, if not controlled. The novel compound, FR, is effective in preventing the bronchial muscle from contracting and relieving spasms. Authors also claim that FR is more effective and has a prolonged time of action compared to the commonly used drug salbutamol. Although the FR treatment worked exceptionally well in mice, a lot of testing needs to be further done before human clinical trials.Advertisement
What happen to lungs in Asthma
Encyclopedia section of medindia explains in brief about what happens to the lungs in Asthma
Encyclopedia section of medindia explains in brief about what happens to the lungs in Asthma
Mechanism of Action of FR
Narrowing of airways leading to shortness of breath is a result of several signaling pathways within the body. Inhibition of these signaling pathways can reduce contraction of the respiratory tract. But in patients with severe asthma, this doesn’t seem to prevent the contractions.Current drugs work by inhibiting a single pathway that results in airway constriction. However, various contracting signals converge on a signaling protein called Gq. This convergence ultimately leads to spasms.
In the airways, Gq-coupled G protein coupled receptors (GPCRs) are thought to play an important role in controlling the tone of airway smooth muscle. FR works by specifically inhibiting Gq thereby inhibiting it from further triggering contractions.
"When we inhibit the activation of Gq proteins with FR900359, we achieve a much greater effect," emphasizes Dr. Michaela Matthey, first author of the study.
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Home Remedies for Asthma
Natural home remedies can offer you an herbal method to treat asthma effectively. Follow these simple home remedies and tips to get rid of asthma.
Natural home remedies can offer you an herbal method to treat asthma effectively. Follow these simple home remedies and tips to get rid of asthma.
Benefit Over Current Drugs
Current treatment options focus on inhibiting a single GPCR at one time. In more severely affected patients, a combination of different drugs is used to inhibit the different pathways. Also, there arise concerns over long term usage of certain medications combined with poor disease control.This means that there is a sub group of patients, who are partially or completely not responding to current GPCR based therapy,
FR based therapy in mouse has proved that the side effects of the treatment are minimal. In fact, the study shows that in the lungs of mice that inhaled FR, airway constriction was prevented with no acute changes in heart rate and blood pressure.
Quiz on Anti-Asthma Medications
Anti-asthma medications include quick relief and long-term medications. Test your knowledge on anti-asthma medication by taking this quiz.
Anti-asthma medications include quick relief and long-term medications. Test your knowledge on anti-asthma medication by taking this quiz.
Future Course of Action
Although scientists have been able to show that bronchial muscle cells isolated from human lungs also inhibit constriction when treated with FR, it could take years before we reach human trials.Reference:
- Matthey, M., Roberts, R., Seidinger, A., Simon, A., Schröder, R., Kuschak, M., Annala, S., König, G., Müller, C., Hall, I., Kostenis, E., Fleischmann, B. and Wenzel, D. (2017). Targeted inhibition of G q signaling induces airway relaxation in mouse models of asthma. Science Translational Medicine, 9(407), p.eaag2288.
