Can Dietary Fiber Reduce Toxins in Urine?

Highlights

Dietary fiber intake can lower uremic toxins in chronic kidney disease (CKD) patients
Uremic toxins accumulate in the body during the course of CKD
The study informs recommendations for using dietary fiber to reducing the uremic toxin among CKD patients in clinical practice

Intake of high fiber foods such as whole breakfast cereals, berries, carrots, broccoli, peas, beans etc., is found to be helpful in decreasing uremic toxins in chronic kidney disease (CKD) condition.

The study published in the Journal of Renal Nutrition assessed the role of dietary fiber supplementation in regulating uremic toxins.

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‘Keep your kidneys healthy by taking fiber enriched-diet and get rid of menacing toxins from your body.’
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Uremic Toxins and Chronic Kidney Disease

Uremic toxins are compounds that are filtered and excreted by the kidneys. In case of CKD (characterized by gradual loss of kidney function) the toxins accumulate and exert their uremic effects on various systems, and may contribute to heart diseases, mineral bone disorders, and death.

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Role of Dietary Fiber in Regulating Uremic Toxins

In a study of 10 randomized controlled trials involving 292 patients, dietary fiber supplements decreased serum levels of indoxyl sulfate, p-cresyl sulfate, blood urea nitrogen, and uric acid.

The study was conducted by Xiao-Hua Wang PhD, of The First Affiliated Hospital of Soocow University in Suzou, China.

The investigators found no significant differences between fiber supplement dosage, and intervention. Studied fiber supplements included brans, lignin, cellulose, arabinoxylan, inulin, beta-glucan, guar gum, gum acacia, pectin, psyllium, fructo-oligosaccharides, and resistant starch.

Dietary fiber supplements did not drastically lower serum creatinine levels in the main analysis but in the subgroup analyses showed a marked 1.04 higher creatinine drop ‘in supplemented patients without diabetes compared with controls. The researchers believed that people with diabetes took more proteins and had higher creatinine productions.

The study indicates that dietary fiber supplementation can significantly lower the levels of uremic toxins in CKD patients, with evidence for a more obvious effect of patients on dialysis and without diabetes.

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Benefits of Fiber Diet

Normalizes bowel health
Lowers cholesterol
Helps relieve constipation
Maintains blood sugar levels
Keeps weight under control

Fiber can Prevent Deterioration of Inner Colon Mucus Layer
Low-fiber diet can alter the composition of colonic microbiota, increases bacterial penetrability and reduces the growth rate of the inner mucus layer.

Fiber Rich Foods

The best fiber enriched choices can be-

Fruits such as apple, pear, raspberry, banana, oranges, etc
Vegetables such as artichokes, broccoli, carrots, turnips, etc
Whole grain products
Nuts and seeds
Peas, beans and other legumes

How to Prevent Chronic Kidney Disease?

Leading a healthy lifestyle is essential for keeping blood sugar levels and blood pressure under control, both are largely responsible for causing chronic kidney disease.

Here are the effective ways to prevent chronic kidney disease-

Restrict or limit salt and fat intake
Exercise for atleast 30 minutes
Get regular health check-ups
Avoid the use of tobacco
Say no to alcohol

References :

The Role of Dietary Fiber Supplementation in Regulating Uremic Toxins in Patients With Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials: Hui-Li Yang et al: Journal of Renal Nutrition 2021: (DOI:https://doi.org/10.1053/j.jrn.2020.11.008)
Improving Your Health With Fiber - (https://my.clevelandclinic.org/health/articles/14400-improving-your-health-with-fiber)

Source-Medindia