New Drug That Reduces Tissue Damage After Heart Attack

MitoSNO, a new drug that can reduce tissue damage to the body after a heart attack has been tested successfully on mice. It may reduce reperfusion injury in heart attack and stroke.

A new drug that may reduce damage to the heart after a heart attack has been developed by a team of U.K researchers. The drug named MitoSNO has already been tested successfully on mice, and is about to be tested on humans.

A heart attack deprives the tissues of the heart, brain and other vital organs of oxygen during the event, and once blood flow to the tissues is restored suddenly after the attack, drastic damage occurs. This is because of the production of harmful molecules called free radicals. The free radicals are generated in the previously oxygen-starved cells by mitochondria (commonly known as the powerhouses of a cell). Free radicals called Reactive Oxygen Species (ROS) cause what is known as ischemia-reperfusion injury in heart attack and stroke.

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Thus logically, switching off the mitochondria for a while during the critical time of reperfusion would prevent damage caused by free radicals to the heart and other tissues. This is what is done by MitoSNO. “MitoSNO effectively flicks a switch in the mitochondria,” says Dr Mike Murphy from the Medical Research Council Mitochondrial Biology Unit, who led the study.

The study was partly funded by the British Heart Foundation; researchers are optimistic about human trials of the drug. The promising potential of the drug may save a large number of heart attack survivors from carrying the burden of heart failure.

The mechanism of the drug can also help other situations like a stroke or a major surgery where tissues remain deprived of oxygen for a long time.

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"We are hopeful that if human trials of MitoSNO are successful it could eventually be used in many other areas of medicine," says the researcher. The report has been published in the journal, Nature Medicine.

Source-Medindia

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