A NK3 receptor blocker may emerge as an alternative to hormonal replacement therapy (HRT) for the treatment of hot flashes during menopause.
Highlights:
A new drug being tested in clinical trials appears to be very effective in treating frequent menopausal hot flashes, and could be a good alternative to hormonal replacement therapy (HRT). The study that evaluated the drug was published in The Lancet.
The menopausal period in women is often uncomfortable due to the appearance of hot flashes. The woman feels a lot of heat in her body, and can even get drenched in the subsequent sweating. Frequent hot flashes could keep the woman grounded during this time. HRT has been used to supplement the reducing estrogen levels and relieve the symptoms. Some women, however, cannot take HRT if they are at risk for breast cancer or blood clots. Other medications are also available, but are associated with side effects.- Menopausal hot flashes are commonly treated with hormonal replacement therapy (HRT)
- Several women cannot or do not prefer to use HRT
- A new option that blocks NK3 receptors in the brain could emerge as an alternative for these women
What is Menopause?
Menopause is defined as the state of permanent cessation of menstrual cycles (periods) for 12-months.
Menopause is defined as the state of permanent cessation of menstrual cycles (periods) for 12-months.
‘A new medication will hopefully be useful to treat frequent hot flashes associated with menopause in women who cannot take hormonal replacement therapy.’
Researchers tested a new compound, currently named MLE4901, in women who suffered from more than seven hot flashes per day. The compound acts by blocking the NK3 receptors through which a brain chemical called neurokinin B (NKB) acts. The levels of neurokinin B (NKB) have been found to be high in the brain tissue of menopausal women. The study included 37 women, out of which 28 completed the trial. The women were between 40 and 62 years of age and did not have a period in at least the previous year. They did not receive any other treatment for their hot flashes for at least 8 weeks before the study. Around half of them received a daily dose of 80 mg for 4 weeks, and a placebo for another 4 weeks with a gap of two weeks in between. The other half had the placebo first and then the drug.
The researchers found that:
- The number of hot flashes reduced by almost 73%
- The severity and impact of the hot flashes including that on sleep also reduced
- Side effects were minimal. Three women experienced rise in a liver enzyme, which normalized within 90 days of stopping treatment
Menarche at Young Age Increases Risk of Premature And Early Menopause
Women who begin their menstrual cycle before they turned 11, have an increased risk of attaining menopause when they are 40 or even younger.
Women who begin their menstrual cycle before they turned 11, have an increased risk of attaining menopause when they are 40 or even younger.
- Prague JK et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial. The Lancet. DOI: http://dx.doi.org/10.1016/S0140-6736(17)30823-1
Source-Medindia
Quiz on Menopause
Menopause is inevitable in a woman’s life and it would be apt to be well prepared for it. Learn more about menopause and the best ways of managing it by going through this quiz.
Menopause is inevitable in a woman’s life and it would be apt to be well prepared for it. Learn more about menopause and the best ways of managing it by going through this quiz.
Menopause Weight Gain
Menopause and weight gain in menopause often go hand in hand. But with simple lifestyle changes, menopause weight gain can be easily managed.
Menopause and weight gain in menopause often go hand in hand. But with simple lifestyle changes, menopause weight gain can be easily managed.
