Osimertinib for Lung Cancer Available Through NHS

The availability of the anti-cancer drug osimertinib through the NHS will make it more accessible to EGFR T790M-positive lung cancer patients in the UK.

Highlights

Mutations in EGRF (epidermal growth factor receptor) predispose to non-small cell lung cancer (NSCLC).
The cancer can therefore be treated with drugs called EGFR tyrosine kinase inhibitors (EGRF-TKI) which include erlotinib, gefitinib, and afatinib.
Patients on EGRF-TKIs soon develop resistance to treatment. Newer drugs like osimertinib may benefit these patients.

A recently licensed drug osimertinib will now be available through the Cancer Drugs Fund (CDF) in the United Kingdom, according to the National Institute for Health and Care Excellence (NICE). The move will benefit around 300 people per year in England and Wales who require the medication for lung cancer.

Osimertinib is an oral medication used for the treatment of an advanced cancerous tumor of the lung called non-small-cell lung cancer (NSCLC) with a specific mutation, known as EGFR T790M-positive. The presence of the mutation is detected through a blood test.

Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.

‘Osimertinib will now be accessible to patients of EGFR T790M-positive non-small-cell lung cancer through the NHS in the United Kingdom.’

There are several types of non-small cell lung cancer like squamous cell carcinoma, large cell carcinoma and adenocarcinoma.

Exposure to cigarette smoke, radiation or occupational pollutants can predispose to NSCLC. It is often diagnosed late and has a poor prognosis. Mutations in EGRF (epidermal growth factor receptor) cause the lung cells to grow into cancer. Therefore, a group of drugs called EGFR tyrosine kinase inhibitors (EGRF-TKI) are used to treat it. Drugs in this group are erlotinib, gefitinib, and afatinib. Unfortunately, EGRF-TKIs become ineffective after being used for a few months following the development of resistance due to mutations like the T790M mutation in the EGRF gene. The newer EGRF-TKI osimertinib also targets the T790M mutation, and is therefore used in the treatment of resistant cancers. Osimertinib provides the last chance of hope for these cancer patients.

Lung Cancer - Facts and Statistics

Lung cancer is the second most common cancer in both men and women
About 224,390 new cases of lung cancer in 2016
14% of new cancers diagnosed are lung cancers
Lung cancer accounts for about 1 out of 4 cancer deaths
It mainly occurs in older people
Smoking is the primary cause of lung cancer

Being a targeted therapy, osimertinib mainly acts against cancer cells, with lesser side effects to the other organs of the body as compared to some other anti-cancer drugs.

Quiz on Lung Cancer
Lung cancer and smoking are closely associated. Lung cancer risk increases with the intensity of smoking. For more details, take this quiz.

Common side effects include diarrhea, skin rash, dry skin, and nail changes. More serious adverse effects include lung and heart disease. Osimertinib should not be used in pregnancy.

Though short-term results of studies indicate that this new drug is advantageous, sometimes even bringing an apparent cure from cancer, its long-term effectiveness will be determined through ongoing clinical studies.

Quiz on Lung Cancer (Advance)
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in both men and women. Test your knowledge on lung cancer by taking this quiz.

References:

NICE Recommends New Drug Osimertinib for Hundreds of People with Lung Cancer - (https://www.nice.org.uk/news/article/nice-recommends-new-drug-osimertinib-for-hundreds-of-people-with-lung-cancer)
Non-Small Cell Lung Cancer Treatment - (https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq)
Highlights of Prescribing Information - (http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/208065s000lbl.pdf)
Key Statistics for Lung Cancer - (http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-key-statistics)

Source-Medindia

Lung Cancer
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