Plastic Pollution Enters Human Placenta

Microplastic fragments were found in the human placenta in the fetal, maternal, and amniochorial membranes.

Highlights:

Microplastics (MP) were detected in human placentas
The microplastic fragments were identified in all placental sections - fetal, maternal, and amniochorial membranes
The microplastics carry with them substances which act as endocrine disruptors and could cause adverse pregnancy outcomes including preeclampsia and fetal growth restriction

Microplastics (MP) are particles with size smaller than five millimeters and are derived from the degradation of the plastic objects present in the environment. A study which analyzed six human placentas found the presence of microplastic particles in them.

The study conducted by Antonio Ragusa and his colleagues at the Department of Obstetrics and Gynecology, San Giovanni Calibita Fatebene fratelli Hospital, Italy, is published in the journal Science Direct. According to the data, in the last century, the global production of plastics reached 320 million tons (Mt) per year, and over 40 percent is used as single-use packaging that increases the plastic waste. When released into the environment, these plastics undergo degradation to form micro and nanosized particles.

Microplastics can move from the environment into living organisms and several reports have found their presence in food, drinking water, seafood, sea salt, the gastrointestinal tract of animals, and also in human intestines.

Microplastics can have long term effects on human health.

Regular Exercise during Pregnancy can Keep Your Placenta Healthy
Is it safe to exercise during pregnancy? Yes, exercising regularly during pregnancy can keep your placenta healthy and also improve your metabolism.

‘Microplastic fragments were detected in four of the six human placentas in the fetal, maternal, and amniochorial membranes. These fragments are harmful and can lead to adverse pregnancy outcomes including preeclampsia and fetal growth restriction.’
Read More..

Analyzing the Placenta

For the study, six human placentas were collected from consenting women with physiological pregnancy and analyzed by Raman Microspectroscopy to determine the presence of microplastics. A plastic- free environment was adopted during the study to prevent contamination.

The placenta was divided into three sections - the fetal side, the maternal side, and the chorioamniotic membranes (part of the amniotic sac that surrounds and protects the fetus).

On analysis, 12 microplastic fragments ranging from 5 to 10 micrometer in size were found in four of the six placentas. Out of the 12 fragments, five were found on the fetal side, four on the maternal side and three in the chorioamniotic membranes.

All the fragments were pigmented with man-made paints, coating, plasters, fiber paints, adhesives, polymers, cosmetics, and personal care products. Some pigments found were iron hydroxide oxide yellow used for coloration of plastics and rubber and a wide variety of cosmetics like BB creams and foundations.

Pigment copper phthalocyanine and phthalocyanine are used for staining plastic materials and for finger paint. The pigment ultramarine blue is used as pigments in cosmetics like soap, lipstick, eye shadow, mascara, and other make-up products. The pigment violanthrone is used for textile dyeing, adhesives, fragrances, air fresheners, and coating products.

Quiz on Pregnancy
There is a general belief that a pregnant woman should eat for two people. How far is this true? This compilation of information, presented in the quiz, will tell you more.

Effect on Fetus

The placenta is a barrier present between the fetus and mother that provides oxygen and nutrients to the baby and removes the waste products from the baby’s blood. It also helps to differentiate between self and non-self, necessary for immunity.

This mechanism can be disturbed due to the presence of microplastics as they accumulate in the body and show toxicity by enhancing and or inducing immune response. This can hamper the defense mechanisms against pathogens and change the utilization of energy stores.

Micro plastics enter the maternal bloodstream by the respiratory and the gastrointestinal tract after which it can reach the placenta.

Top 7 Eco-friendly Substitutes for Plastic Bags
Plastic bags are silently killing our planet. Finding eco-friendly substitutes to plastic bags can be the best solution to keep our environment clean and green. So, just say 'No' to plastic bags and grab these 7 eco-friendly bags to get rid of plastic pollution.

Effect On Pregnancy

Microplastics can alter several cellular regulating pathways in placenta like:

Immunity mechanisms during pregnancy
Functions of atypical chemokine receptors governing maternal-fetal communication growth-factor signaling during and after implantation
Signaling between the embryo and the uterus, and
Trafficking of immune cells like natural killer cells, macrophages, T cells, and uterine dendrite cells during normal pregnancy.

These effects can lead to adverse pregnancy outcomes like fetal growth restriction and high blood pressure during pregnancy (preeclampsia) that can lead to organ damage.

Scientists Develop Novel Recyclable Plastic
Plastics can now be recyclable. Scientists have designed a recyclable plastic that can be broken down and rebuilt into another plastic item of different shape, color, size or texture, The quality of plastics can be retained and can be used for a different purpose.

Conclusion

The placenta plays an important role in supporting the fetus development and in acting as an interface between the fetus and the external environment. The presence of such harmful plastic particles is a matter of great concern.

Transgenerational (trauma transferred through generations) effects of plastics on metabolism and reproduction can affect pregnancy outcomes and fetus.

Additional studies need to be performed to determine if the presence of microplastics in the human placenta can trigger immune responses or the release of toxic contaminants that can be harmful to the pregnancy.

Reference :

Plasticenta: First evidence of microplastics in human placenta; Antonio Ragusa et al; Environmental International Volume 146, January 2021; https://doi.org/10.1016/j.envint.2020.106274

Source-Medindia