Renal Denervation may not alter Endothelial Function and Inflammatory Markers

Renal denervation led to reductions in BP, and muscle and renal sympathetic activity. But, there were no changes in endothelial function and inflammatory markers.

Renal denervation reduces high blood pressure in resistant cases of hypertension, but does not affect endothelial function and inflammatory markers, revealed a new study. The findings were presented at the 23^rd European Meeting on Hypertension and Cardiovascular Protection.

Renal artery denervation, also called renal ablation is a minimally invasive procedure where the nerves in the renal artery (the artery supplying to the kidney) are disrupted. This procedure has been found to be useful in patients with hypertension that is resistant to usual treatment. It reduces blood pressure in these patients and the effect has been maintained for more than 24 months.

High Blood Pressure
High blood pressure or hypertension is defined as a blood pressure of above 140 mm Hg (systolic) and or 90mm Hg (diastolic).

Hypertension is known to be associated with inflammation of blood vessels and endothelial dysfunction (endothelium is the inner layer of the blood vessels). Researchers carried out a study to determine whether treatment with renal denervation can also reduce vascular inflammation or affect endothelial function.

A study was conducted in 63 patients with resistant hypertension at an average age of 61 years. At the beginning of the study, the study participants had a high body mass index, and were taking an average of 4.6 medications for hypertension.

After renal denervation, BP was significantly reduced from 169/90 mmHg at baseline () to 156/84 mmHg three months following the procedure. This reduction was sustained even at 12 months follow-up. Also, there was no significant change in the heart rate.

Renal Denervation After Ablation Reduces Recurrent AF
Recurrent atrial fibrillation is reduced when renal denervation is performed with pulmonary vein isolation ablation in patients with AF and hypertension, suggests a research.

The researchers found that there was no significant change in endothelial function and various inflammatory markers from the baseline at the end of 3 months after the administration of renal denervation. Only the level of nonesterified fatty acid (NEFA) significantly decreased, which was possibly due to reduced nervous activity in the adipose tissue following the procedure. The activity of the sympathetic nervous system was reduced in the muscle and kidneys, but the whole body sympathetic activity did not change significantly over 3 months.

The researchers thus concluded that though renal denervation causes a reduction in blood pressure, it does not affect vascular inflammation and endothelial function.

Renal Denervation That Includes Accessory Arteries Found More Successful
Reducing blood pressure in patients with resistant hypertension using renal denervation seems to be more successful when it includes accessory renal arteries, suggests a study.

Source-Medindia

In Advanced Heart Failure Renal Denervation Gives Better Outcomes Than Drugs
According to research, renal denervation leads to better outcomes than standard drug treatment in patients with advanced heart failure. The research was presented at ESC Congress 2012.