Diabetes during Pregnancy May Increase Depression Risk after Childbirth

Mothers diagnosed with gestational diabetes mellitus have a high risk of developing postpartum depression symptoms.

Highlights:

Mothers with gestational diabetes mellitus (GDM) have a higher risk of developing depression symptoms after childbirth and type 2 diabetes later in life
Postpartum depression symptoms were found in 16 percent of mothers diagnosed with gestational diabetes

Gestational diabetes mellitus (GDM) may increase the risk of developing postpartum depression symptoms and type 2 diabetes later in life, reports a new study. The findings of the study are published in the Journal of Affective Disorders.//

Gestational diabetes mellitus refers to impaired glucose metabolism during pregnancy.

Gestational Diabetes About
The condition is not caused by a lack of insulin, but by the action of hormones produced during pregnancy that blocks the action of insulin.

‘Gestational diabetes (GDM) may be associated with an increased risk of postpartum depression. Being diagnosed with a disease during pregnancy that might harm the fetus can be a stressful experience, which may lead to depression symptoms.’

Often, mothers with GDM have too high blood glucose levels, and this increases the risk of various adverse effects on the fetus. Moreover, GDM increases the mother's risk of developing type 2 diabetes later in life.

Postpartum depression symptoms are experienced by 10-15 percent of mothers after childbirth. The newly published study used the Edinburgh Postnatal Depression Scale to assess depression symptoms during the third trimester of pregnancy and eight weeks after delivery.

Postpartum depression symptoms were observed in 16 percent of mothers diagnosed with GDM, and in approximately nine percent of mothers without GDM. The researchers used statistical methods to adjust the results for other factors contributing to the risk of GDM and postpartum depression symptoms, such as maternal age at delivery, body mass index and depression symptoms experienced during pregnancy.

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Conducted by the University of Eastern Finland, the University of Helsinki, Kuopio University Hospital and the Finnish National Institute for Health and Welfare, the study pooled data from Kuopio Birth Cohort, which is an ongoing follow-up of women from the beginning of their pregnancy. Altogether, 1,066 mothers with no previous mental health issues were selected for the study.

"Psychological mechanisms may partially explain the observed association between GDM and postpartum depression symptoms," says Doctoral Student Aleksi Ruohomäki, the first author of the study. "Being diagnosed during pregnancy with a disease that might harm the fetus can be a stressful experience, which may predispose to depression symptoms."

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"Furthermore, physiological mechanisms may also contribute to this association," adds Dr. Soili Lehto, Group Leader of Kuopio Birth Cohort's mental well-being section. "Impaired glucose metabolism may increase cytokine-mediated low-grade inflammation, which has also been associated with depression. Previous studies have also shown that type 2 diabetes predisposes to depression, and depression to type 2 diabetes".

Research evidence is scarce regarding the possible effects of GDM on postpartum depression symptoms, and the new Finnish study is an essential contribution to this emerging area of research.

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Source-Eurekalert