NeXT Personal, a liquid biopsy test offers early lung cancer detection through ctDNA analysis, improving survival predictions and personalized treatment.
Highlights:
Lung cancer is one of the most common types of cancer and the leading cause of cancer-related deaths worldwide. Early detection of lung cancer is important for personalized treatment and to increase the chances of survival. Traditional methods like low-dose CT scan (LDCT), x-ray, and ultrasound are used for diagnosis which may not be sensitive enough to detect early-stage lung cancer (1✔ ✔Trusted Source- NeXT Personal liquid biopsy enables early lung cancer detection by identifying ctDNA in blood with high sensitivity
- High-quality tumor samples were used for precise genomic sequencing
- The test reliably detects ctDNA, predicting survival outcomes and aiding personalized cancer treatment
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
Go to source). Liquid biopsy is a non-invasive test that can analyze bodily fluids for cancer detection at early stages. NeXT Personal is a highly sensitive blood test that can detect circulating tumor DNA (ctDNA) in the blood.
Cell-Free DNA (cfDNA) Application in Cancer Detection
cfDNA offers a non-invasive approach for early cancer detection, monitoring treatment response, and identifying relapses, aiding in improved patient outcomes.
cfDNA offers a non-invasive approach for early cancer detection, monitoring treatment response, and identifying relapses, aiding in improved patient outcomes.
‘NeXT Personal helps detect #lungcancer early, personalize treatment, and monitor recovery with a simple blood test. #liquidbiopsy #cfDNA #medindia’
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NeXT Personal: Early Cancer Detection Made Easy
The test can help doctors understand cancer cells' behavior, predict its spread, and find a suitable treatment. It can detect early-stage cancers, like lung cancer, where the amount of ctDNA is very low.The NeXT Personal platform shows high sensitivity in detecting ctDNA preoperatively, offering valuable prognostic information for early-stage lung cancer detection. The test can detect minimal residual disease (MRD) or early recurrence, indicating that the cancer is progressing or returning, rather than causing it to worsen. The test predicted the overall survival (OS) and recurrence-free survival (RFS), making it a powerful tool for understanding how likely someone is susceptible after surgery or treatment.
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Lung Cancer - Types, Causes, Symptoms, Diagnosis, Treatment and Prevention
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Ethical Study on Lung Cancer
The study was conducted ethically, following all necessary guidelines. Patients with stage I–IIIB non-small cell lung cancer (NSCLC) who have to undergo surgery were selected for the study. Consent was obtained from all patients and their data was anonymized for privacy concerns.Tumor tissue samples were collected and preserved by formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF). Over time, the quality of some FFPE samples declined due to DNA degradation. The data was checked for its reliability.
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Quiz on Lung Cancer
Lung cancer and smoking are closely associated. Lung cancer risk increases with the intensity of smoking. For more details, take this ...
Lung cancer and smoking are closely associated. Lung cancer risk increases with the intensity of smoking. For more details, take this ...
Genomic Sequencing for Personalized Cancer Care
The genome was sequenced using advanced DNA technology to find specific mutations that can cause cancer. This information was used to personalize treatment for each patient.Customized panels were developed to detect circulating tumor DNA (ctDNA) in patients’ blood. These panels targeted specific mutations unique to each patient’s cancer. The technique had high sensitivity enough to detect very low levels of ctDNA.
Artificial Intelligence Detects Lung Cancer Before Radiologists
Artificial intelligence (AI)-based deep learning technology can detect lung cancer faster and more accurately than radiologists. This will make lung cancer diagnosis easier and help save many lives.
Artificial intelligence (AI)-based deep learning technology can detect lung cancer faster and more accurately than radiologists. This will make lung cancer diagnosis easier and help save many lives.
ctDNA Testing: Tracking Cancer with Precision
Different factors like the amount of input DNA and sequencing depth were analyzed to ensure reliable results. DNA signals from normal cells were removed to focus only on cancer-related DNA.The test showed strong accuracy in detecting ctDNA in the blood. The results were consistent regardless of the amount of DNA used in testing or the sequence depth making it a promising tool for monitoring cancer progression, treatment, and detecting recurrence early.
Reference:
- Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma - (https://www.nature.com/articles/s41591-024-03216-y)
Source-Medindia
