Organophosphate pesticides are powerful pesticides that help kill pests. Being exposed to these harmful chemicals can increase your risk of Covid-19 infection.
Highlights:
- Being exposed to organophosphate pesticides can increase your risk of Covid-19 infection
- Also, people with diabetes and cancer are at an increased susceptibility to SARS-CoV-2 infection
- Therefore, be extra careful and stay away from pesticides to keep Covid-19 infection at bay
Exposure to organophosphate pesticides causes Gulf War Illness -- a cluster of medically unexplained chronic symptoms that can include fatigue, headaches, joint pain, indigestion, insomnia, dizziness, respiratory disorders and memory problems.
The team examined whether exposure to the organophosphate pesticide chlorpyriphos and increased levels of interleukin 6 (IL-6) could increase risk of SARS-CoV-2 infection.
For six hours, they exposed human lung airway epithelial cells to either IL-6 or chlorpyriphos or to both in combination. Another group of cells received no exposure to serve as a control.
The researchers then treated the cells with the spike proteins that cover the outside of SARS-CoV-2. During infection, spike proteins bind with angiotensin converting enzyme 2 (ACE2) receptors to our cells, starting a process that allows the virus to release its genetic material into the healthy cell.
The cells exposed to both the pesticide and IL-6 also had significantly more ACE2 expression on the apical cell surface compared to cells that were unexposed or exposed to the pesticide alone. The apical membrane of airway cells faces the interior of the airway while the basolateral membrane touches the surrounding tissues. Increased ACE2 receptor expression on the apical surface means more viruses will attach to the cells, the researchers explained.
The findings were presented at the virtual Experimental Biology (EB) 2021 meeting.
Source-IANS