How Does Wine Protect the Neurons From Parkinson’s Disease?

Food compounds in wine are responsible for this health benefit in protecting against the onset of neurodegenerative diseases.

Highlights

Wine intake, in moderation, does wonders to the body, be it reducing cholesterol levels or nourishing the skin.
Wine also has the ability to delay aging and the onset of Parkinson’s and Alzheimer’s disease.
Compounds that are left after the wine has passed through the gut protect the cells from dying due to stress.

Moderate wine intake can be beneficial in delaying the onset of cognitive impairments in aging and neurodegenerative diseases like Parkinson’s and Alzheimer’s disease.

Dr. Esteban-Fernández from the Institute of Food Science Research in Madrid and her colleagues investigated the compounds that are left after the wine has passed through the gut: the so-called wine-derived human gut metabolites.

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‘The intestinal flora breaks down the wine into the different metabolites which are active at different points in the cell signaling cascade that is leading to this cell death.’

They selected some of these metabolites based on their presence in the urine and feces of people consuming wine on a regular and moderate basis.

To explore the neuronal effect of these compounds, they added them to human cells under stress conditions that normally lead to neuronal cell dysfunction and death. These conditions are related to the initial stages of some neurodegenerative disorders.

They found that the metabolites are protecting the cells from dying due to the stress conditions. The most striking result, however, was that the metabolites are active at different points in the cell signaling cascade that is leading to this cell death.

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The exact composition of the wine metabolites is therefore important in the protective neuronal effect. And this composition depends on your gut microbiota composition, as the intestinal flora breaks down the wine into the different metabolites.

"In other words, differences in our gut microbiota are leading to the different metabolites. Which underpins the idea that humans benefit from food in different ways", Dr. Esteban-Fernández explains.

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"This individual difference is a factor not to be neglected to understand the health effects of certain foods. We are now in need to advance our understanding of the effect of diet in the promotion of normal brain function."

"It is very important to understand that certain food compounds are responsible for this health benefit in protecting against the onset of neurodegenerative diseases; no medication was involved. I am not advocating to replace medicines by diet, but I want to raise more awareness how your diet is helping to prevent diseases or reduces the risk of getting sick. It is more than feasible to go to the supermarket and buy vegetables and fruit: it depends only on the individuals to maintain a balanced diet."

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As she works on the role of diet in health maintenance and disease prevention, Dr. Esteban-Fernández takes her own nutrition very seriously.

"I am really aware about the importance of a healthy diet enriched in vegetables, fruits, and reduced industrial saturated fats. Although I try to maintain my dietary habits as good as possible, I think it is also important to not get too obsessed. Society is nowadays full of false myths about diet, and it is the role of both science and media to avoid the spread of these rumors, as well as make people aware of the importance of diet for your health."

Reference

Esteban-Fernández et al., Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action, Frontiers in Nutrition (2017) http://dx.doi.org/10.3389/fnut.2017.00003.

Source-Medindia