Kidney Damage Impairs Cognitive Functioning

Highlights

Kidney damage was linked with worse performance on tests of global cognitive function, executive function, memory and attention.
Kidney damage may also be linked with structural abnormalities in the brain.

People with kidney disease are at high risk of cognitive impairment.

The nature of this relationship remains uncertain, but a new analysis investigates this link between kidney disease and cognitive impairment.

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‘It may be possible to treat kidney diseases by educating health professionals and scientists, advancing research and innovation, and advocating for the highest quality care for patients.’

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It will be presented at American Society of Nephrology-ASN Kidney Week 2016 November 15¬-20 at McCormick Place in Chicago, IL.

Kidney failure-

Kidney failure is also called end stage renal disease (ESRD). It is the last stage of chronic kidney disease.

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When the kidney functions continue to get worse over time, it is chronic kidney disease.The causes of chronic kidney disease includes diabetes, blood pressure, autoimmune conditions, genetic disorders or urinary tract problems.

When the kidneys stop functioning suddenly, it is acute renal failure. Its common causes are heart attack, drug abuse, block in blood flow to kidneys or urinary tract disorders.

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Symptoms of kidney failure include itching, muscle cramps, diarrhea/ difficulty breathing and sleeping, loss of appetite, swelling of feet and ankles, backache, nausea and vomiting.

Facts-

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Kidney disease is the 9th leading cause of death in the United States. Around 31 million people ( 10% of the adults population) have chronic kidney disease (CKD).

Though women are more likely to suffer from CKD, men have 50% greater chances of the developing end stage renal disease.

Compared to whites, the risk for kidney failure among Asians are 4.1 times higher.

Diabetes accounts for 44% of all new kidney failure cases and high blood pressure causes 28.4% of all new cases of kidney failure.

Study-

For the analysis, Daniel Weiner, MD, FASN (Tufts Medical Center) and his colleagues gathered information from the Systolic Blood Pressure INTervention (SPRINT) cognition substudy, SPRINT-MIND.

Among 9361 participants, 2800 were administered an expanded cognitive battery at the start of the study and 2707 had complete data; 637 also had brain imaging.

Predictors of poor kidney function

Higher albumin in urine
Lower rate of glomeruli filtration

After adjusting for various demographic and clinical characteristics, higher albumin in the urine, which is indicative of poor kidney function, was linked with worse performance on tests of global cognitive function, executive function, memory, and attention.

Each doubling of the amount of albumin in the urine was akin to the effect of 6 to 14 months of aging in these cognitive domains.

Lower estimated glomerular filtration rate, another indicator of poor kidney function, was linked with worse performance on tests of global cognitive function and memory.

In the subset of participants with brain imaging, higher albumin in the urine was associated with abnormal white matter regions in the brain.

"This manifests with worse brain function, particularly in domains linked to cerebrovascular disease. The fact that this comes from baseline data in the SPRINT trial suggests that these findings are likely relevant to tens of millions of US adults.," said Dr. Weiner.

The findings cement the association between kidney damage and cognitive functioning, suggesting that albumin in the urine and changes in brain structure are likely both representations of the same vascular process, just in different organs.

References

Kidney failure/ESRD - (http://www.kidneyfund.org/kidney-disease/kidney-failure/?referrer=https://www.google.co.in/)
2015 Kidney Disease Statistics - (http://www.kidneyfund.org/assets/pdf/kidney-disease-statistics.pdf)

Source-Medindia