Olive Leaf Extract Could be the Next Treatment for Endometriosis

In a recent animal study, it is seen that olive leaf extract could be an effective non- hormonal therapy for endometriosis.

Highlights:

Endometriosis is a disease where tissue similar to the lining of the uterus grows outside the uterus, causing pain and infertility
Endometriosis depends on estrogen which is a female reproductive hormone //
Current hormonal treatments for endometriosis can cause hot flashes, tiredness, headache, depression, joint and muscle stiffness, and vaginal dryness

Olive leaf extract, also known as oleuropein, has been shown in a recent study on endometriosis-affected mice to boost fertility, slow the progression of the condition, and have no negative side effects. It is also cheap and natural.

Endometriosis, a condition characterized by pelvic pain, menstrual cramps and infertility. Endometriosis develops when tissue like the lining on the inside of the womb grows outside of the uterus, which may swell and bleed, leading to pain and other symptoms. In a recent study, olive leaf extract known as oleuropein has shown to suppress endometriosis progression and improve the fertility of mice with endometriosis ().

Estrogen and Endometriosis

Endometriosis depends on estrogen, a hormone well known for regulating a woman’s reproductive functions. Estrogen also affects other organs such as the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, pelvic muscles and the brain.

‘Olive leaf extract, oleuropein suppresses progression of endometriosis and improves the fertility in mice with endometriosis, according to a study conducted in mice.’

Endometriosis’ dependence on estrogen and inflammation has guided treatments that are based on systematically removing estrogen and using anti-inflammatory drugs. However, current endometriosis treatments have low efficacy, high recurrence rate and cause adverse effects in other tissues affected by estrogen.

Since endometriosis is an estrogen-dependent disease, estrogen receptors (ERs) ER-alpha and ER-beta, which mediate the hormones’ effects on cells, play essential roles in the development and progression of the condition. These findings suggest that selectively suppressing the activity of ER-beta could help treat the condition without side effects of current hormonal therapies targeting ER-alpha.

Olive Leaves as Treatment for Endometriosis

The researchers found that oleuropein, a natural component found in olive leaves, selectively inhibits ER-beta activity, but not ER-alpha activity, and effectively suppresses the growth of mouse and human endometriosis lesions in mouse models. In addition, oleuropein treatment was neither toxic to the liver nor did it affect the ability of female mice to have offspring. In mice with endometriosis, oleuropein improved the pregnancy rate.

Natural products have been widely and globally used in various preventive and therapeutic health care formats. Unlike synthetic compounds, natural products are generated by enzymatic interactions. The biological activity of natural products involves protein‒protein binding, making them more effective drug candidates. In addition, natural products are a product of evolutionary pressure that results in their novelty. Natural products are more prone to bioactivity than synthetic compounds. For example, 48.6% of cancer drugs have natural origins or are derived from natural products. Therefore, natural products could also be employed to treat endometriosis as non hormonal therapies ().

Uterus Bioengineering Using Stem Cells May Help Treat Endometriosis
Endometriosis could soon be treated using stem cells (iPS cells) that can be induced to produce healthy uterine cells to replace the diseased tissue. A bioengineered uterus could be developed in the future, using this strategy.

In addition, olive leaf extracts have various beneficial effects on human health, such as antimicrobial, antiviral, antioxidant, anti-inflammatory, anti aging-associated neurodegeneration, and anticancer effects.

It is metabolized in vivo into elenolic acid and hydroxytyrosol by beta-glucosidase and esterase activity in humans and mice. Hydroxytyrosol is also one of the major components in olive leaf extracts and has antiproliferative, antioxidant, and anti-inflammatory effects on various human cancers.

Nanoparticles Show Promise for Locating Endometriosis Lesions
A new nanotechnology approach developed by researchers helps locate and remove the painful and dangerous lesions associated with endometriosis.

These promising findings support further exploration of the value of oleuropein as naturopathy for human endometriosis treatment. Oleuropein is less expensive than hormonal therapy, and the current findings suggest that it is safer than current treatments.

References:

Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis - (https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-022-00883-2)
Natural Products: Source of Potential Drugs - (https://idosi.org/ajbas/ajbas6(6)14/3.pdf)

Night Shifts Linked to Irregular Periods And Endometriosis In Women
Working in night shifts could predispose women to irregular menstrual cycles and a higher risk of developing endometriosis (chronic painful disorder).

Source-Medindia