Pathology: Cornerstone of Modern Medicine

Pathology is more than just diagnosing disease. It’s about understanding the causes, progression and finding solutions. This International Pathology Day, let's appreciate pathologists.

Highlights:

Pathologists play an important role in diagnosing and understanding diseases
International Pathologists Day is celebrated every year during the second week of November
The theme for the year 2024 is ‘The rise of global Antimicrobial Resistance (AMR)’

Pathology, often referred to as the cornerstone of modern medicine, plays an important role in understanding and diagnosing diseases. Pathologists serve as detectives in the medical field solving some of the most complex cases ().

Antimicrobial Resistance: The Emerging Threat Amplified by Air Pollution
The alarming connection between air pollution and the rise of antibiotic resistance, a global health concern with far-reaching consequences.

‘Did You Know?
With tools like digital pathology and AI, pathologists are making faster, more accurate diagnoses. Pathology is transforming into one of the most tech-driven areas of healthcare! #digitalpathology #AI #medindia’

Role of Pathology in Medicine

Pathology is an interesting field that sits at the intersection of science, medicine and investigative work. Pathologists examine tissues, cells and body fluids to determine the underlying causes of diseases and to guide suitable treatment plans.

Pathology has many subfields cytopathology, forensic pathology and neuropathology, these fields provide a better scope for understanding diseases.

Pathology with the help of cutting-edge technologies such as digital pathology, artificial intelligence (AI) tools enables pathologists to make faster, more precise diagnoses, transforming the field into one of the most tech-driven areas of medicine.

Drug Resistance – Antibiotic or Antimicrobial Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.

International Pathology Day 2024

International pathology day is celebrated annually during the second week of November. This year it is on November 6. The day is dedicated to raising awareness about the crucial role of pathology in healthcare and highlighting the essential contributions of pathologists to patient care.

Observed all over the world, it emphasizes the importance of laboratory medicine in diagnosing diseases, planning treatment and improving patient care.

The common theme for this year is “The rise of global Antimicrobial Resistance (AMR)”. Antimicrobial resistance is one of the most stressful global threat in today’s world. If no precautionary measures are taken, 10 million people each year could die from effects of AMR by 2050.

The Growing Threat of Antimicrobial Resistance
Antimicrobial resistance is rising, threatening global health. Urgent action and awareness are needed to combat this growing crisis and protect public health.

Antimicrobial Resistance

Antimicrobial resistance is a condition where bacteria, viruses, and fungi no longer respond to antimicrobial medications, rendering them ineffective in treating infection and leads to chronic infections ().

AMR is a natural process that occurs over time through genetic changes in pathogens. This is due to human activity due to overuse or misuse of drugs to control disease in humans, animals and plants.

Antimicrobial Resistance Turning into Reality
Antibiotic resistance, which is indeed a global threat to health and well-being of people, is part of a bigger problem called antimicrobial resistance (AMR).

Role of Pathology in AMR

There are various mechanisms through which AMR is developed. The known pathological mechanisms are

Pathogens undergo genetic mutation that makes them resistant to effect of antimicrobial drugs which alters the target sites of antibiotics, decreasing the drug's effectiveness.
Horizontal gene transfer mechanisms such as transformation, conjugation and transduction play an important role in rapid spread of AMR among microorganisms.
Some bacteria form biofilms, a protective layer that acts as a shield for them against the antimicrobials, and this biofilm can be a reason for chronic infections which are difficult to treat.
Bacteria possess efflux pumps that can flush out antimicrobial agents from their cells, which reduces medication effect to sub-lethal levels.
Certain pathogens produce enzymes that inactivate effect of antimicrobial agents, which results in ineffectiveness of medications.

Pathologists help in identifying resistant microorganisms through advanced diagnostic methods and provide an understanding of resistance patterns through susceptibility testing. This can help healthcare professionals to plan targeted therapies.

Importance of pathology in disease diagnosis, treatment plans and understanding disease progress is invaluable. The contribution made by pathologists in healthcare system must be appreciated.

References:

Pathology: The Cornerstone of Modern Medicine and a Fascinating Field of Study - (https://indiaeducationdiary.in/pathology-the-cornerstone-of-modern-medicine-and-a-fascinating-field-of-study/)
Antimicrobial resistance - (https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance)

Source-Medindia