Plant-Based Compounds can Treat Prostate Cancer

Compounds found in turmeric, and red grapes can inhibit the growth of prostate cancer. Combining two compounds were found to be effective in preventing cancer.

Highlights:

Compounds found in plants have anti-cancer properties
Turmeric, apple peel, and red grapes contain compounds that prevent the growth of cancer tumors
Combining the active ingredients such as curcumin, resveratrol and ursolic acid can be effective in inhibiting cancer growth, finds a new study

Natural compounds found in turmeric, apple peels, and red grapes can thwart the growth of prostate cancer, finds a new research from The University of Texas. Prostate cancer is the most common cancer among men. //

So whenever we are eating a curry, baked apples we are preventing the growth of cancer, said the research team.

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‘Curcumin in turmeric, resveratrol in red grapes and ursolic acid in apple peel can prevent the growth of prostate cancer.’

For the study, the research team used a novel analytical approach to screening several plant-based chemicals instead of testing a single compound as many studies do. The team studied specific combinations that could shrink prostate cancer tumors.

"After screening a natural compound library, we developed an unbiased look at combinations of nutrients that have a better effect on prostate cancer than existing drugs. The beauty of this study is that we were able to inhibit tumor growth in mice without toxicity," said, Stefano Tiziani, assistant professor in the Department of Nutritional Sciences and Dell Pediatric Research Institute at UT Austin.

In the last decade, studies have highlighted the potential therapeutic compounds found in plants, including chemical in foods such as turmeric, apple peels, red grapes and green tea. These compounds reduce the risk of cancer by fighting inflammation within the body. People who have chronic inflammation due to infection, autoimmune disease or conditions such as obesity are at higher risk of developing cancer because of damage to normal cells.

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Initially, the research team tested 142 natural compounds in mouse models and human cell lines to see which compound inhibited prostate cancer cell growth. They tested the cancer-preventing effects of the compound by testing alone and in combination with another compound.

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Some of the active ingredients that were tested on animal models were:

Ursolic acid - a natural waxy chemical found in apple peels and rosemary
Curcumin - the bright yellow compound in turmeric
Resveratrol - a natural compound found in red grapes and berries

"These nutrients have potential anti-cancer properties and are readily available. We only need to increase concentration beyond levels found in a healthy diet for effect on prostate cancer cells," said Tiziani.

The study published online in Precision Oncology demonstrates how the plant-based chemicals work together.

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The research team found that combining ursolic acid with curcumin or resveratrol prevented the cancer cells from growing by inhibiting glutamine. The team concluded that the plant-based chemicals blocked the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly found in the food.

Reference:

Alessia Lodi, Achinto Saha, Xiyuan Lu, Bo Wang, Enrique Sentandreu, Meghan Collins, Mikhail G. Kolonin, John DiGiovanni, Stefano Tiziani. Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism. Precision Oncology, (2017); 1 (1) DOI: 10.1038/s41698-017-0024-z

Source-Medindia