A commonly used pyridoxine-doxylamine drug for morning sickness is tested for its efficacy in an unpublished research.
- Nausea during the first trimester of pregnancy is referred to morning sickness.
- Pyridoxine-doxylamine drug is an antihistamine drug used for the treatment of morning sickness.
- An unpublished research questions the efficacy of a commonly used pyridoxine-doxylamine drug for morning sickness.
Morning Sickness
“Morning sickness” is a term that is used to refer to the nausea and vomiting that is present in most pregnant women.
“Morning sickness” is a term that is used to refer to the nausea and vomiting that is present in most pregnant women.
‘The efficacy of a commonly used pyridoxine-doxylamine drug for morning sickness is questioned.’
The study was published by Dr. Nav Persaud, family physician, research scientist at St. Michael’s Hospital, restoring invisible and abandoned trials (RIAT) initiative which has unpublished studies that are difficult to determine the treatment options. Pyridoxine-doxylamine drug sold under the name Diclectin was tested for its efficacy to treat morning sickness in the first trimester of pregnancy.
Even though the results of the clinical trial was not published, regulatory bodies like Health Canada and the United States Food and Drug Administration (USFDA) has collected information to approve the drug.
Morning Sickness Now Linked to Healthier Babies
New research confirms that women plagued by morning sickness in early pregnancy are less likely to suffer from miscarriage.
New research confirms that women plagued by morning sickness in early pregnancy are less likely to suffer from miscarriage.
According to the Society of Obstetricians and Gynecologists of Canada, the drug is considered to be a standard of care for women with nausea and vomiting "since it has the greatest evidence to support its efficacy and safety."
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Home Remedies for Morning Sickness
Morning sickness can mar your joy during first trimester of your pregnancy. Here are some tips on home remedies for morning sickness.
Morning sickness can mar your joy during first trimester of your pregnancy. Here are some tips on home remedies for morning sickness.
Clinical Trial
The clinical trial was conducted on 2308 pregnant women who were experiencing nausea and vomiting. The data was collected from 14 clinics in the United States. These women were divided into eight groups, out of which one received placebo and other seven groups received combination of drugs.
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Pregnant Women with Morning Sickness should be Prescribed Drugs: UK Doctors
Morning sickness in pregnant women could be mild or severe. Some moms-to-be have severe symptoms and anti-sickness drugs could be beneficial urged UK doctors.
Morning sickness in pregnant women could be mild or severe. Some moms-to-be have severe symptoms and anti-sickness drugs could be beneficial urged UK doctors.
Dr. Persaud’s Conclusions
- No availability of the final study results.
- Even though the trial lasted for a week, there was an increased number of participants who did not complete it.
- Physicians did not score the symptoms clearly.
- Data was unavailable for 37% of patients in the placebo group
- Unable to contact the researchers since most of them had died
- Data collected from 30patients were excluded due to an order of the Commissioner of Food and Drugs in a 1975 letter which stated“ data recording in absence of patient visits”.
Nausea that occurs during the first trimester of pregnancy is referred to as Morning Sickness.
Around 7 in 10 women experience morning sickness during pregnancy.
Morning sickness which sometimes requires hospitalization may be called Hyperemesis gravidarum.
Symptoms of Morning Sickness
- Nausea
- Vomiting
- Anxiety and depression
- Loss of appetite
Doxylamine is a sedative antihistaminic drug which is marketed along with pyridoxine for the treatment of morning sickness.
Side Effects of Pyridoxine-Doxylamine
- Dry mouth
- Drowsiness
- Abdominal Upset
- Vertigo
Source-Medindia
