Medications commonly used for heartburn, reflux and ulcers have damaging effect on kidneys.
- Individuals who took proton pump inhibitors (PPI)or histamine receptor-2 (H2)blockers for heartburn, acid reflux, or ulcers had elevated risks of developing kidney stones.
- In individuals without acute kidney injury, PPI’s were linked with a higher risk of developing chronic kidney disease or kidney failure compared with histamine receptor-2 blockers.
Gut Microbiome Diversity Decreased by Proton Pump Inhibitors
Gut bacteria diversity was found to decrease with regular intake of proton pump inhibitors, increasing the risk of infections like clostridium difficile and pneumonia.
Gut bacteria diversity was found to decrease with regular intake of proton pump inhibitors, increasing the risk of infections like clostridium difficile and pneumonia.
‘Being vigilant in PPI and H2 use, even in the absence of acute kidney disease and careful attention to kidney function in these medication users may be a reasonable approach.’
Proton pump inhibitors (PPIs) and histamine receptor-2 (H2) blockers are commonly used to reduce gastric acid production. Kidney stones-
To see if these drugs increase the risk of developing kidney stones, Pietro Manuel Ferraro, MD, MS, PhD (Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, in Rome, Italy) and his colleagues examined information on 187,330 participants of the Health Professionals Follow-up Study (HPFS) and Nurses' Health Study (NHS) I and II who were initially free of kidney stones.
Long-Term Proton Pump Inhibitors Use Accelerates Aging of Blood Vessels
PPIs were the third-most taken type of drug in the U.S and are believed to account for $13 billion in annual global sales.
PPIs were the third-most taken type of drug in the U.S and are believed to account for $13 billion in annual global sales.
After adjusting for a number of factors such as age, race, body mass index, physical activity, smoking status, comorbidities, use of medications, and intake of nutrients, use of PPIs was associated with a 12% higher risk of developing a kidney stone, and use of H2 blockers with a 13% higher risk.
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Esophageal Disorders - Achalasia Esophagitis Gastroesophageal reflux disease (GERD)
Esophagus is the tubular structure that carries food, liquids and saliva from mouth to the stomach. esophageal disorders are common but lack a well-defined pathogenetic mechanism.
Esophagus is the tubular structure that carries food, liquids and saliva from mouth to the stomach. esophageal disorders are common but lack a well-defined pathogenetic mechanism.
"Use of PPIs and H2 blockers is associated with a small increase in risk of incident kidney stones. Further studies are needed to confirm our findings and to investigate whether the excess risk is related to a particular type of kidney stones such as those made of calcium oxalate," said Dr. Ferraro.
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In a second study, Yan Xie, MPH (VA Saint Louis Health Care System) and his colleagues examined current assumptions that chronic kidney disease that may arise after use of PPIs is secondary to incomplete recovery from acute kidney injury (AKI).
When the investigators analyzed information in the Department of Veterans Affairs national database on 152,157 users of PPIs or H2 blockers, PPI use was associated with a greater than 30% higher risk of developing CKD or a combined endpoint of kidney failure or more than 50% decline in estimated glomerular filtration rate (a measure of kidney function) compared with H2 blocker use in the absence of AKI.
"Reliance on AKI as a marker of potential adverse renal events in those treated with PPI is not sufficient," said Xie
Exercising vigilance in PPI use--even in the absence of AKI--and careful attention to kidney function in PPI users may be a reasonable approach.
Source-Medindia
