Remote-Controlled Drug Delivery Implant for Astronauts

Patients requiring daily medicines but lack access to healthcare may receive prolonged, adjustable doses due to a new remotely controlled drug delivery system.

Highlights:

Experts will soon e testing a novel remotely controlled drug delivery implant that can ultimately be used even in space to deliver medication and treat astronauts
The implant uses nanofluidics technology to diffuse a controlled medicine dose

One day, patients who require daily medication but do not have access to healthcare could receive extended, adjustable treatment, even on Mars-bound spacecraft, thanks to a novel remotely controlled drug delivery implant. Such an implant has been created by experts at Houston Methodist Research Institute. To test whether the implant can be operated in space from a device on Earth, they are using the International Space Station (ISS) National Laboratory.

The investigation will create the framework for subsequent tests from the research team using mouse models on the ISS, which will launch on SpaceX’s forthcoming 26th Commercial Resupply Services mission (SpaceX CRS-26). According to Alessandro Grattoni, professor of nanomedicine at Houston Methodist Research Institute, the objective is to increase the implant’s capacity to communicate with Earth and guarantee that the medication delivery mechanism is secure for use by people.

Drug Delivery System
Drug delivery systems, is a technology using various chemicals to bind the target drugs, carry them to target organ, tissue or cell where the drug is released at a pre-determined rate.

‘An innovative remotely controlled drug delivery device may one day allow patients who need daily medicine but lack access to healthcare to obtain prolonged adjustable treatment.’

Medicine in Space

“We’re preparing for the first demonstration of a remotely controlled telemedicine implant in an animal model on the ISS. It’s the ultimate sci-fi medicine in space,” Grattoni said. “And beyond our investigations, the implant could provide a valuable technology for drug dosing in rodent research studies with no need for astronaut time.”

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Nanofluidics Technology for Remotely Operated Drug Delivery System

To diffuse a controlled medicine dose, the implant uses nanofluidics technology, which combines membranes with incredibly narrow nanochannels. The research team’s earlier work, funded by the ISS National Lab, looked at fluid flow through nanochannels to design the implant’s capacity to release precise dosages of medication for customized treatment. Grattoni also oversaw an investigation that examined the implantable nanochannel drug delivery system’s capacity to lessen microgravity-caused muscular atrophy in a rodent model.

For the current inquiry, Grattoni and his colleagues will utilize the Faraday Research Facility created by ISS National Lab Commercial Service Provider ProXopS, LLC to evaluate their remotely controlled implant in an automated experiment. To serve as a ‘surrogate animal model’, the implant is submerged in liquid saline and equipped with technology resembling a computer chip. To test various frequencies and see if the implant can precisely deliver and adjust doses when instructed, the researchers will attempt to control the implant using Bluetooth and a Blackberry device on Earth.

Oncology Drug Delivery Systems
Drug delivery in oncology offers a localized, prolonged and protected drug interaction with the cancer cells and reduces the side effects.

Drug Delivery Implant for Use in Space

The investigation’s findings will be a crucial step in developing the implant for use by astronauts who may require safe, automated access to a medication that needs to be taken frequently. The consequences of radiation or prolonged exposure to microgravity in space, for instance, may one day be lessened with the use of a treatment that is now in development.

“Radiation exposure is a limitation for taking people to Mars, and even the Moon,” Grattoni said. “Other precautionary methods are being developed to prevent radiation exposure, but our device will be the first that a doctor back on Earth could use to instantly deliver medication to treat an exposed astronaut during a long-term mission.”

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Smartphones Manage Medicine Delivery Implants Remotely

Additionally, Grattoni’s team has created implants with several reservoirs that enable the simultaneous dosing of several medications. Even better, the implant can be pre-programmed, making it easier for it to work when communications with Earth are difficult or delayed. By using an application on their smartphone or computer, clinicians on Earth will eventually be able to manage medicine delivery implants wherever their patients are located- from isolated areas of Earth to far-off space, according to Grattoni.

Source-Medindia