Sleep Hormone Pill Can Worsen Gut Inflammation

Highlights:

Melatonin, commonly known as the "sleep hormone," can have adverse effects on gut health
The balance of gut microbiota plays a crucial role in maintaining overall health
Caution should be exercised when considering melatonin supplementation and its potential impact on inflammation and gut microbiota

Melatonin, often referred to as the "sleep hormone" due to its role in regulating sleep cycles, has long been recognized for its antioxidant properties. However, a recent study has shed light on the potential adverse effects of melatonin on gut health, specifically exacerbating intestinal inflammation and impairing the action of gut microbiota (). In this article, we delve into the findings of this study and explore the intricate relationship between melatonin, gut microbiota, and inflammation.

Melatonin
Melatonin is the body’s master hormone with several significant functions, including the monitoring of other hormones and regulating the sleep-wake cycle.

‘Unveiling the hidden effects of melatonin on gut health. Explore the intricate link between the 'sleep hormone' and inflammation, and the implications for supplementation. #Melatonin #GutHealth’

Significance of Gut Microbiota

The gut is home to a complex community of bacteria and other microorganisms, collectively known as gut microbiota. This microbial ecosystem plays a crucial role in maintaining overall health, contributing to digestion, nutrient absorption, and supporting the immune system. A healthy balance of beneficial and harmful microbes is essential for optimal bodily functions. Imbalances in gut microbiota have been associated with various disorders, including weight gain, high blood sugar levels, and abnormal cholesterol levels.

Melatonin Helps Treat Sleep Disorders in Neuro-Developmentally Challenged Children
Sleep disturbances are generally chronic and lead to behavioral and learning problems. Children having developmental and neurological ailments show high prevalence of sleep disturbances.

Melatonin and Its Widely Used Supplement

Melatonin supplements, often marketed as natural sleep aids, are commonly consumed without a doctor's prescription by individuals struggling with sleep problems. Melatonin is generally regarded as safe due to its hormonal nature and potential sleep-regulating benefits. However, the recent study led by Professor Cristina Ribeiro de Barros Cardoso from the University of Sao Paulo, Brazil, has raised concerns about the potential adverse effects of melatonin on overall health.

Sleep Hormone Melatonin may Aggravate Bowel Inflammation
Researchers evaluated the effects of the sleep hormone melatonin in colitis that evolves with intestinal dysbiosis, inflammation, and bacterial translocation.

Melatonin's Impact on Intestinal Inflammation

The study, published in the journal Microorganisms, involved inducing colitis, an inflammatory condition of the colon, in mice and treating them with melatonin (). Surprisingly, the mice's condition worsened instead of improving upon melatonin administration. Professor Cardoso emphasizes that the study solely involved animal subjects and not human patients. Nevertheless, the research unveiled the negative impact of melatonin on gut health. The detrimental effects were observed when considering the interaction between melatonin and gut microbiota, specifically the association with inflammatory diseases in the intestinal region.

Melatonin Use Curtails the Risk of Self-Harm in Young People
Sleep interventions such as melatonin treatment could be considered to reduce the risk of self-harm in young females with depression and anxiety, instead of medications.

Role of Gut Microbiota

The delicate balance of gut microbiota is crucial for maintaining a healthy digestive system and a well-functioning immune response. Certain characteristics of gut microbiota can contribute to inflammation and disrupt immune system regulation when exposed to melatonin, ultimately damaging the digestive system.

The Cautionary Message: Hormone Supplements and Food Supplements

Professor Cardoso emphasizes the importance of exercising caution when it comes to medications, hormone supplements, and even substances marketed as food supplements. Melatonin, despite being widely available as a "food supplement," is, in fact, a hormone. The intricate interactions between hormones and the immune system highlight the delicate nature of their regulation within the body. In conclusion, while melatonin continues to play a vital role in sleep regulation and as an antioxidant, a recent study suggests that its use as a supplement should be approached with caution. The intricate relationship between melatonin, gut microbiota, and inflammation warrants further research to fully understand the underlying mechanisms. As always, consulting healthcare professionals and being mindful of potential effects is crucial when considering hormone supplements or any substances marketed as food supplements.

References:

Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice - (https://pubmed.ncbi.nlm.nih.gov/34451919/)
The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation - (https://www.mdpi.com/2076-2607/11/2/460)

Source-Medindia