Graves' disease patients found that smoking increases the risk of surgical intervention for thyroid eye disease.
Highlights:
smoking was associated with an increased risk of surgical intervention for treating thyroid eye disease (TED) in the Intelligent Research in Sight (IRIS) Registry, according to researchers from the Departments of Ophthalmology Boston Children's Hospital and Massachusetts Eye and Ear, Harvard Medical School, Boston, US.
- Current smokers had a higher risk of undergoing orbital decompression, strabismus surgery, and eyelid recession surgery
- Former smokers had a lower risk than current smokers, but higher than never smokers
- Smoking cessation can help lower the burden of surgical disease for thyroid eye disease
Treatment for Thyroid Eye Disease May Impair Hearing
Ear, Hearing Loss, Thyroid Eye Disease, Teprotumumab, Muffled Hearing
Ear, Hearing Loss, Thyroid Eye Disease, Teprotumumab, Muffled Hearing
‘New study shows smoking increases the risk of surgical intervention for thyroid eye disease. Quitting smoking can help lower the burden of surgical disease. #thyroideyedisease #smokingcessation’
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Study on Graves' Disease Patients: TED Surgery Requirement and Patient Characteristics
The authors conducted a retrospective cohort study on persons with Graves' disease who were registered in the IRIS Registry between January 1, 2013, and December 31, 2020. The key outcome was the requirement for TED surgery, including orbital decompression, strabismus surgery, and eyelid recession surgery. There were 87,774 patients in this study (mean age, 59 years; 81% female).Advertisement
Teprotumumab, First FDA-approved Drug for Thyroid Eye Disease Proves Effective
For patients with thyroid eye disease, teprotumumab was found to decrease the inflammation in the eye and the build-up of tissues behind the eye that produce the long-term symptoms that reduce quality of life, stated study.
For patients with thyroid eye disease, teprotumumab was found to decrease the inflammation in the eye and the build-up of tissues behind the eye that produce the long-term symptoms that reduce quality of life, stated study.
People who Smoke are at Higher Risk of Eye Surgeries
The findings revealed that current smokers had a higher 5-year cumulative likelihood of undergoing orbital decompression (3.7% vs 1.9%; P 0.001), strabismus surgery (4.6% vs 2.2%; P 0.001), and eyelid recession (4.1% vs 2.6%; P 0.001).After controlling for demographic characteristics (age, gender, race, ethnicity, and geographic region), current smokers had a higher risk of orbital decompression, strabismus surgery, and eyelid recession (P 0.001 for all comparisons) than never smokers. Former smokers were more likely to need each of the procedures, but their risk was lower than that of current smokers.
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New Underlying Mechanisms of Proptosis in Patients With Acute Thyroid Eye Disease
New underlying mechanisms of proptosis, or bulging of the eyes, in patients with acute thyroid eye disease have been identified by researchers.
New underlying mechanisms of proptosis, or bulging of the eyes, in patients with acute thyroid eye disease have been identified by researchers.
Importance of Quitting Smoking to Improve Eye Health
The authors concluded, “Smoking was associated with increased risk of surgical intervention for TED in the IRIS Registry. Former smokers were at a lower risk than current smokers, supporting the role of smoking cessation in lowering the burden of surgical disease at the population level.”Source-Medindia
US FDA Approves 1st Drug for Thyroid Eye Disease Treatment
US Food and Drug Administration (FDA) approves the first drug called Tepezza for the thyroid eye disease treatment, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to be pushed forward and bulge outwards.
US Food and Drug Administration (FDA) approves the first drug called Tepezza for the thyroid eye disease treatment, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to be pushed forward and bulge outwards.
