Stress Regulating Protein can now help Decrease the Risk of Diabetes

FKBP51, a well known stress regulating protein can now be blocked to decrease the risk of diabetes and obesity.

Highlights

FKBP51 protein found in the muscle can promote diabetes and obesity in people who consume unhealthy diet
An unhealthy diet, rich in fat can induce stress in the body and thereby increase the production of FKBP51 protein
Increased production of FKBP51 protein can lead to changes in glucose absorption and intolerance leading to diabetes

Diabetes and obesity can now be promoted by a stress regulating protein called as FKBP51. This protein if not regulated can cause glucose intolerance in the body causing diabetes. The findings of this study are further discussed in the journal of Nature Communications.

For some time, researchers have known that the protein FKBP51 is associated with depression and anxiety disorders. It is involved in the regulation of the stress system - when the system does not function properly; mental disorders may develop.

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‘Antagonistic approach to this FKBP51 protein can prevent diabetes development in individuals who consume a lot of calories or are under stress. Less FKBP51 in the muscle tissue can mean reduced glucose intolerance and normal functioning of metabolism.’

Now, researchers at the Max Planck Institute of Psychiatry have discovered a new, surprising role for this protein: It acts as a molecular link between the stress regulatory system and metabolic processes in the body.

"FKBP51 influences a signaling cascade in muscle tissue, which with excessive calorie intake leads to the development of glucose intolerance, i.e., the key indicator of diabetes type 2," project leader Mathias Schmidt summarizes.

An unhealthy diet, rich in fat means stress for the body. If FKBP51 is increasingly produced in the muscle it leads to reduced absorption of glucose - as a result, diabetes and obesity may develop.

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If FKBP51 is blocked, diabetes will not develop, even if too many calories are consumed or the body is still stressed. Less FKBP51 in the muscle tissue means reduced glucose intolerance and thus maintenance of normal metabolism.

The protein FKBP51 can be pharmacologically blocked by antagonist compounds that were developed at the Max Planck Institute by Felix Hausch (presently at University of Darmstadt).

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In collaboration with the scientists at the Technical University Darmstadt and funded by the Bavarian State Ministry of Economic Affairs and Media, Energy and Technology, these compounds will be further developed for use in clinical trials.

"These findings may provide a completely new treatment approach for diabetes and other metabolic diseases," states Alon Chen, Director at the Max Planck Institute of Psychiatry.

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References

Georgia Balsevich, Alexander S. Häusl, Carola W. Meyer et.al. Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function, Nature Communications (2017).DOI:10.1038/s41467-017-01783-y

Source-Eurekalert