Heart Drug may Up Cancer Risk

In men, use of amiodarone drug was found to increase the risk of developing cancer, shows study published in CANCER. Amiodarone was approved in 1985 for the treatment of arrhythmias, or irregular heartbeats. Because the drug is fat-soluble and degrades very slowly, large amounts can accumulate in soft tissues after a long-term prescription. Previous studies have shown that amiodarone might increase the risk of certain cancers, but no large-scale study has looked at the issue.

To investigate, Vincent Yi-Fong Su, MD, of the Taipei Veterans General Hospital in Taiwan, and his colleagues studied 6,418 individuals taking the drug, following them for an average of 2.57 years. A total of 280 participants developed cancer.

Patients who were male or who received high cumulative daily doses of amiodarone within the first year had an increased risk of developing cancer. Those with both factors were 46 percent more likely to develop cancer than those with neither factor. After taking age, sex, and illnesses into account, individuals taking a high amount of amiodarone had nearly twice the risk of developing cancer as those taking a low amount of the drug.

"We suggest that cancer events should be routinely reported in future amiodarone trials, and further observational research is necessary," said Dr. Su. "Also, when prescribing amiodarone, doctors need to keep in mind that this medication may increase cancer risk."

Source-Eurekalert