Increased levels of acetylation of mitochondrial proteins involved in energy metabolism subsequently contribute to the development of heart failure.
Link Between Heart Failure and Red Meat, Discovered
Red meat contains L-carnitine which is broken down to trimethylamine N-oxide (TMAO), a metabolite, found in heart failure patients.
Red meat contains L-carnitine which is broken down to trimethylamine N-oxide (TMAO), a metabolite, found in heart failure patients.
‘Heart failure is a condition in which the heart’s muscle becomes weakened after a heart attack or high blood pressure and loses its ability to pump enough blood to supply the body’s needs.’
In this month's issue of JCI Insight , Daniel Kelly of the Sanford Burnham Prebys Medical Discovery Institute and his coauthors sought to explore how post-translational modification of mitochondrial proteins involved in energy metabolism contributes to the development of heart failure. Using an unbiased screen to look for changes in protein acetylation, the researchers profiled heart tissue from 5 end-stage heart failure patients who went on to receive heart transplants.
They found that failing cardiac tissue had increased levels of acetylated mitochondrial proteins. Further, in a mouse model, they detected elevated levels of mitochondrial protein acetylation at the earliest stages of heart failure.
7 Important Measures to Reduce Heart Failure Risk
A new study published in the journal Circulation: Heart Failure has come up with seven most important measures that people can use to rate their heart health.
A new study published in the journal Circulation: Heart Failure has come up with seven most important measures that people can use to rate their heart health.
Collectively, their work suggests that mitochondrial protein hyperacetylation may promote the metabolic defects seen in heart failure.
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Men, Women may Need Gender-Specific Heart Failure Treatment
Johns Hopkins scientists shed light on different forms of heart failure seen in men and women that may require the development of gender-specific treatments.
Johns Hopkins scientists shed light on different forms of heart failure seen in men and women that may require the development of gender-specific treatments.
Study Provides Fresh Molecular Insight into Heart Failure
New research from scientists at Sanford Burnham Prebys Medical Discovery Institute may lead to a new approach to help treat heart failure early in the disease.
New research from scientists at Sanford Burnham Prebys Medical Discovery Institute may lead to a new approach to help treat heart failure early in the disease.
