High Cholesterol In Midlife Increases Dementia Risk Later In Life

Increased cholesterol levels in midlife significantly increase the risk of Alzheimer's disease and vascular dementia in later life, says a new study.

Increased cholesterol levels in midlife significantly increase the risk of Alzheimer's disease and vascular dementia later in life, suggests a new study.

The study by researchers at Kaiser Permanente's Division of Research and the University of Kuopio in Finland appears in the journal Dementia and Geriatric Cognitive Disorders.

High Cholesterol | Hypercholesterolemia - Causes, Symptoms, Diagnosis & Treatment
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the wall of the arteries and clog the circulation posing a threat to life.

The four-decade study of 9,844 men and women found that having high cholesterol in midlife (240 or higher milligrams per deciliter of blood) increases, by 66 percent, the risk for Alzheimer's disease later in life.

Even borderline cholesterol levels (200 - 239 mg/dL) in midlife raised risk for late-life vascular dementia by nearly the same amount: 52 percent.

Vascular dementia, the second most common form of dementia after Alzheimer's disease, is a group of dementia syndromes caused by conditions affecting the blood supply to the brain.

Alzheimer’s disease - Causes, Symptoms, Diagnosis, Stages, Types, Prevention, Prognosis & Treatment
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.

Scientists are still trying to pinpoint the genetic factors and lifestyle causes for Alzheimer's disease.

By measuring cholesterol levels in 1964 to 1973 based on the 2002 Adult Treatment Panel III guidelines (the current practice standard) when the Kaiser Permanente Northern California members were 40 to 45 years old, then following the participants for 40 years, this study is the largest long-term study with the most diverse population to examine the midlife cholesterol levels and late-life dementia.

Diseases Related to Old Age
Ageing is referred to the accumulation of changes that brings a person closer to death.

"Our study shows that even moderately high cholesterol levels in your 40s puts people at greater risk for Alzheimer's disease and vascular dementia decades later," said the study's senior author.

Rachel Whitmer, Ph.D., a research scientist and epidemiologist at the Kaiser Permanente Division of Research in Oakland, Calif.

"Considering that nearly 100 million Americans have either high or borderline cholesterol levels, this is a disturbing finding. The good news here is that what is good for the heart is also good for the mind, and this is an early risk factor for dementia that can be modified and managed by lowering cholesterol through healthy lifestyle changes," the expert added.

Source-ANI
THK