High-salt Diet can Reduce Tumor Growth by Tackling Immune Cells

Too much salt can fight cancer. Eating a salty diet can inhibit tumor growth by tackling immune cells, reveals a new study.

Salty diet can play a key role in the inhibition of tumor growth by just tackling the immune cells, reports a new study.

A study by an international research team led by Professor Markus Kleinewietfeld (VIB-UHasselt) shows that high salt intake inhibits tumor growth in mice. The effect seems to be due to a change in the function of certain immune cells, which play a critical role in cancer immunity. The further exploration of this finding might be beneficial for improving anti-cancer immunotherapies.

Make Your Food Taste Salty without Using as Much Sodium Chloride: Study
Want a low salt diet without compromisation in the taste? A new study finds a way to make food taste salty but with less of the sodium chloride which is related to poor health.

‘Eating a salty diet can fight tumor growth. A new study suggests that increasing the salt in the diet can reduce tumor growth by tackling immune cells.’
Read More..

Salt Impacts Experimental Tumor Models

High salt intake is a known risk factor for high blood pressure and cardiovascular diseases. Recent research has also indicated that too much salt may impact autoimmunity. Studies have shown that a high salt diet could change the immune cell balance towards a more aggressive state and worsen autoimmunity. Interestingly, these shifts in the immune cell balance, though detrimental in autoimmune conditions, could be in theory useful in anti-cancer immune therapies to improve immune attacks against tumor cells.

An international research team led by Prof. Kleinewietfeld that included Prof. Sven Brandau (University of Duisburg-Essen, Germany), Dr. Thomas Kammertöns (Charite & MDC-Berlin, Germany) and Prof. Jo Van Ginderachter (VIB-VUB) have now investigated the impact of high salt intake on tumor growth in mice. They found that a high salt diet inhibited tumor growth in two independent mouse models.

Role of Dietary Sodium To Prevent Future Diseases
Limiting your sodium and fluid intake will help prevent and control the amount of fluid around your heart, lungs, or in your legs.

The research team further found that this effect seemed to be related to a change in the functions of certain immune cells, so-called myeloid-derived suppressor cells (MDSCs). MDSCs are believed to hinder other immune cells to efficiently attack and eliminate tumor cells.

Immune Cells Changing Function

Iodised Salt: Good or Bad for Your Health?
Consuming iodized salt regularly could do more harm than good. Excess intake of iodine can cause several forms of rhythm disturbances in heart, and lead to heart failure.

When the researchers mimicked a salty environment in cell culture, they observed a functional change in MDSCs. The cells were less capable to inhibit other immune cells. A similar modulatory effect of high salt conditions on MDSCs was observed with cells isolated from human cancer patients. Moreover, if these cells were depleted, the effect of a high salt diet on tumor growth in mice was undone.

MDSCs are suspected to be an important mechanism that prevents an efficient immune attack against tumors in anti-cancer immunotherapies. The underlying molecular mechanism that blocks the function of these cells could, therefore, have therapeutic potential. However, since high salt intake is suspected to be a risk factor for gastric cancer in humans, the findings of this study and molecular mechanisms behind them must be carefully analyzed in future studies.

Salt and Blood Pressure
Salt is good and essential for health in minute quantities.

Prof. Kleinewietfeld (VIB-UHasselt): "The findings are highly interesting, and we were surprised to see such an effect on tumor growth just by increasing the salt in the diet. However, future studies are needed to fully understand the effect and the detailed underlying molecular mechanisms behind to judge its therapeutic potential for anti-cancer immunotherapies.

Source-Eurekalert