High Urinary Albumin in Type 2 Diabetics Tied to Cardiovascular Risk

Imaging studies in patients with type 2 diabetes who do not exhibit symptoms of cardiovascular disease suggested that high albumin in the urine may be associated with sub-clinical coronary artery pathology, including coronary artery microcalcifications. Positron emission tomography(PET) and computed tomography(CT) scans were the imaging methods used. Results from the study are presented at ASN Kidney Week 2023 November 1–November 5.
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Increased Coronary Artery Pathology in Type 2 Diabetes Without Cardiovascular Disease but with Albuminuria

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Albuminuria- An Early Indicator of Cardiovascular Risk in Type 2 Diabetics

Among 30 individuals with type 2 diabetes and normal urinary albumin levels and 60 with elevated levels (a condition called albuminuria that indicates kidney damage), participants with albuminuria had higher microcalcification activity, but not after adjusting for clinical risk factors for cardiovascular disease.

Microcalcification activity was positively associated with the extent of albuminuria, and a trend remained after adjustment. Average myocardial flow reserve (the ability to increase blood flow in the heart during work) was lower in participants with albuminuria, but not after adjustments. Coronary inflammation activity and coronary artery calcium score were similar between the groups.

“Enhancing the understanding of cardiovascular pathology may in the future help clinicians to identify subpopulations of patients at high risk and provide individualized prevention of cardiovascular complications,” said corresponding author Tine Hansen, PhD, of Steno Diabetes Center Copenhagen, in Denmark.

Reference:

1. Increased Coronary Artery Pathology in Type 2 Diabetes Without Cardiovascular Disease but with Albuminuria - (https://www.asn-online.org/education/kidneyweek/2023/program-abstract.aspx?controlId=3940634)

Source-Eurekalert