Highly Effective Acne Treatments: Oral Isotretinoin and Triple Topical Therapy

In acne treatment it is essential to recognize that oral/topical antibiotics have limited effectiveness for non-inflammatory lesions.

In the comparison of various pharmacological therapies for acne vulgaris, researchers identified oral isotretinoin as the most effective treatment, followed closely by a triple therapy comprising a topical antibiotic, a topical retinoid, and benzoyl //peroxide (BPO) ().

Another triple therapy consisting of an oral antibiotic, a topical retinoid, and BPO also showed substantial efficacy. Among monotherapies, antibiotics or topical retinoids exhibited comparable effectiveness for inflammatory lesions, while antibiotics showed less impact on non-inflammatory lesions.

Understanding Acne

Acne is a common skin disease with an estimated global presence of 9.4% and an annual cost of $3 billion in the United States (). Although guidelines that recommend medications are generally supported by high-quality, randomized controlled trials, research is lacking on the efficacy of certain medications, particularly when comparing treatment options that have markedly inconsistent drug prescribing patterns among countries and among prescriber specialties.

Your Pillowcase Might Be Causing Your Acne Breakouts
The state of your pillowcases may affect your acne. The pillowcase on which, you sleep might be the culprit of your failed beauty care regimen. Read this article to know how pillowcases can cause acne.

‘When it comes to combating acne and achieving clearer skin, two highly effective treatments have shown promising results: oral isotretinoin and triple topical therapy. ’

Based on a comprehensive meta-analysis of 210 articles, comprising 221 trials and examining 37 interventions involving 65,601 patients, researchers have concluded that oral isotretinoin is the most effective treatment for acne.

Following closely behind, triple therapies incorporating a topical retinoid, benzoyl peroxide (BPO) and an antibiotic have shown significant efficacy. For monotherapies, both oral/topical antibiotics and topical retinoids demonstrate comparable effectiveness for inflammatory lesions.

Reference:

Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris - (https://pubmed.ncbi.nlm.nih.gov/37487721/)
Acne clinical guideline - (https://www.aad.org/member/clinical-quality/guidelines/acne)

Source-Eurekalert

Acne - Causes Symptoms Diagnosis Treatment FAQs Videos Glossary Reference
Acne vulgaris, popularly known as ‘pimples’ or ‘zits’ is a skin condition affecting most teenagers.

Quiz on Acne
Acne breakouts affect millions of people worldwide, particularly teenagers. Here’s a quiz on some general facts about acne that you should know.

Quiz on Skin Infections
Skin infections are caused by bacteria, viruses, fungi or parasites. Factors such as injuries, poor hygiene, humidity, and weak immune system increase risk of skin infection.