Hormone replacement therapy (HRT) is the best treatment for POI that gives the body estrogen and other hormones that ovaries are not making.
Primary Ovarian Insufficiency (POI) is a condition characterized by the loss of functions of the ovaries before the age of 40. Hormone Replacement Therapy (HRT) can be effective to treat POI, according to gynecologists. According to //doctors, POI patients can suffer from loss of libido, infertility, poor concentration and night sweating.
‘Hormone replacement therapy involves a combination of estrogen and progestin, which regularizes menstrual cycle and improves sexual health.’
Women during the POI do not have normal amount of estrogen hormone or release eggs regularly. They have premature menopause and stop having periods and cannot get pregnant. The doctors said HRT is an effective treatment for POI.
"HRT is the best treatment for POI that gives the body estrogen and other hormones that ovaries are not making," said Sagarika Agarwal, an expert with city based Indira IVF.
Stating that HRT is usually a combination of an estrogen and a progestin (form of progesterone) to regain the patient's menstrual cycle, she said it also improves the sexual health.
"Progesterone is taken along with estrogen to balance out its effect on the lining of the womb, which even decreases risk of endometrial cancer," said Agarwal.
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"Follicle dysfunction many a times are the major reason in such cases. HRT treatment gives the body the estrogen and other hormones that ovaries are not making," said Archana S. Ayyanathan, a Chennai-based IVF expert.
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"Normally a woman is born with two million primordial follicles (microscopic seeds which grow into follicles), which may get depleted or not function properly to cause POI. Some women are born with fewer primordial follicles, so they have a smaller pool of follicles to use throughout their lives," said Ayyanathan.
"Even though only one mature follicle releases an egg each month, less mature follicles usually develop along with that mature follicle and egg. If these extra follicles are missing, the main follicle will not mature and release an egg properly," added Ayyanathan.
Source-IANS