Hormone Widely Used as an Autism Treatment Shows No Benefit

Multicenter study finds that oxytocin was safe, but ineffective at boosting social skills among children with autism.

Oxytocin, a naturally occurring hormone that acts as a chemical messenger in the brain, showed no evidence of helping children with autism gain social skills, according to a large national study appearing in the New England Journal of Medicine.

“There was a great deal of hope this drug would be effective,” said the study’s principal investigator and lead author, Linmarie Sikich, M.D., associate consulting professor in the Department of Psychiatry & Behavioral Sciences at Duke University School of Medicine.

Autism Causes, Symptoms, Diagnosis, Treatment, Prognosis
Autism is a neurodevelopmental disorder typically characterized by impaired social and communication skills combined with repetitive movements.

‘Oxytocin does not appear to change the social function of people with autism.’

Oxytocin is typically used to induce labor, but because of its activity in the brain, it has been investigated as a treatment for autism.

Evidence has been conflicting, with several smaller studies suggesting it improved social and cognitive function among some children with autism, while other studies showed no benefit.

To investigate this, researchers designed the multi-site trial to provide the best evidence about oxytocin as a safe and effective treatment for children with an autism spectrum disorder.

Rare Genetic Mutations Predict Intellectual Disability in Autism Spectrum Disorder (ASD)
Novel computational model identifies the genes linked to autism that helps in predicting the level of intellectual disability in people with autism spectrum disorders (ASD).

The research team enrolled 290 children ages 3-17, stratified by age and the severity of their autism symptoms. The children were randomized in similar, equal-sized groups to receive oxytocin or a placebo via a daily nasal spray over 24 weeks.

To see if the regimen of oxytocin would have a measurable impact on the children’s social abilities based on screenings and assessments at the start of the trial, midway through, and at the end. Both researchers and the children’s parents provided assessments using standard analytic tools for autism.

A Chemical Oxytocin Sensor may Help Detect Autism at Birth
A chemical love hormone sensor made up of polymer layer with a carefully designed structure can help in early detection of autism in children

While the oxytocin was well tolerated and had few side effects, it showed no significant benefit among the group of children who received it compared to those who received the placebo.

These results indicate that clinicians and families should insist that there is strong evidence for the safety and benefit of new treatments before they are provided to patients in the clinic.

Can Oxytocin Reduce Cravings for Methamphetamine Drug?
Oxytocin, a naturally occurring molecule for social bonding and childbirth could help to reduce the drug-seeking behavior for methamphetamine.

There is no evidence in this large study that is strong enough to justify more investigation of oxytocin as a treatment for autism spectrum disorders.

Source-Medindia