A new study analyzed how abnormal acylcarnitines in 57 NT1 (fatty acid) metabolism influences sleep disorders namely narcolepsy type 1 and other hypersomnia.
Sleep Disorders
Then, it was examined whether rs5770917 in CPT1B gene affects CPT1 activity, because rs5770917 is significantly correlated with lower expression levels of CPT1B gene. No significant correlation between rs5770917 and CPT1 activity was detected in general. However, there was an interaction between BMI (non-obese <25kg/m2 and obese ≥25kg/m2) and rs5770917 (risk+, risk-), and non-obese NT1 patients without the risk allele had higher CPT1 activity.
Circadian Rhythm Sleep Disorders - Types, Causes, Health risks, Diagnosis, Treatment, Prognosis
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that follows an internal cycle of roughly 24 hours.
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that follows an internal cycle of roughly 24 hours.
‘Lower CPT1 activity was identified to be an independent risk factor for both sleep disorders.’
RNA sequencing-based whole transcriptome analysis¡Ðlow expression levels of carnitine shuttle related genes. Transcriptome analysis was carried out in the whole blood samples from 42 NT1 patients and 42 healthy controls. SLC25A20 gene encoding carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase 2 (CPT2) gene involved in the carnitine shuttle had the second and fifth lowest P values, respectively, and the expression levels were lower in the patients. CPT1B gene was not included in differentially expressed genes in NT1.
However, the risk allele of rs5770917 in CPT1B gene suppresses CPT1B expression. No genetic variants significantly correlated with expression levels of SLC25A20 and CPT2 were detected. These results indicated that CPT1B expression levels are downregulated by the genetic factor associated with NT1, while SLC25A20 and CPT2 expression levels in NT1 patients are downregulated by non-genetic factors.
About Hypersomnia
Hyper means “excessive” and somnia refers to “sleep”, so hypersomnia is excessively long or deep sleep despite sleeping for several hours at night.
Hyper means “excessive” and somnia refers to “sleep”, so hypersomnia is excessively long or deep sleep despite sleeping for several hours at night.
Source-Eurekalert
Narcolepsy - Overview Incidence Causes Symptoms Diagnosis Treatment Prognosis Prevention FAQs
Sleep is the blissful state that rejuvenates our mind and body everyday and any deprivation often leads to a disorder that can affect our health
Sleep is the blissful state that rejuvenates our mind and body everyday and any deprivation often leads to a disorder that can affect our health
Test Your Knowledge on Sleep Paralysis
Sleep paralysis is a relatively common condition where a person is unable to move or talk while falling asleep or on waking up. It resolves spontaneously within a few minutes and is not serious. It may occur at any age but most common in adolescents and young adults. For a long time, it was believed to be due to demonic forces and supernatural events, but now we know the scientific basis for this. Test your knowledge on sleep paralysis
Sleep paralysis is a relatively common condition where a person is unable to move or talk while falling asleep or on waking up. It resolves spontaneously within a few minutes and is not serious. It may occur at any age but most common in adolescents and young adults. For a long time, it was believed to be due to demonic forces and supernatural events, but now we know the scientific basis for this. Test your knowledge on sleep paralysis
