How Artificial Intelligence Can Help Treat Opioid Addiction

Approximately three million Americans suffer from opioid use disorder, and every year more than 80,000 Americans die from overdoses. Opioid drugs, such as heroin, fentanyl, oxycodone, and morphine, activate opioid receptors. Activating mu-opioid receptors leads to pain relief and euphoria, but also physical dependence and decreased breathing, the latter leading to death in the case of a drug overdose. Preclinical studies have shown that blocking kappa-opioid receptors may offer a promising pharmacological approach to treating opioid dependence.

By discovering drugs that inhibit the kappa-opioid receptor, researchers hope to alleviate opioid addiction. These findings will be presented at the 67th Annual Biophysical Society Meeting in San Diego, California.

Kappa-opioid receptors are known to mediate brain rewards. After a lot of opioid exposure, your brain gets rewired to need more drugs. Blocking the activity of the kappa opioid receptor has been shown in animal models to reduce this need to use drugs in the withdrawal period.

Use Artificial Intelligence to Develop Drugs that can Treat Opioid Addiction

However, discovering drugs that can block the activity of a protein, such as the kappa-opioid receptor, can be a long and expensive process. Using computational tools can make it more efficient, but it can take months to screen billions of chemical compounds. Instead, the researcher is using artificial intelligence (AI) to optimize the process.

Artificial intelligence has the advantage of being able to take huge amounts of information and learn to recognize patterns from it. So, researchers believe that machine learning can help us to leverage the information that can be derived from large chemical databases to design new drugs from scratch.

Using information about the kappa-opioid receptor and known drugs, they trained a computer model to generate compounds that might block the receptor with a reinforcement learning algorithm that rewarded properties that are favorable for drug treatments.

So far, the team has identified several compounds that have promising properties and they are working with collaborators to synthesize them and eventually test their ability to block the kappa-opioid receptor in cells, before testing them in animal models for safety and effectiveness. Let us all hope that it can help people struggling with addiction.

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Source-Eurekalert