How Does COVID-19 Turn on Immune Response in the Brain?

A new study provides the first evidence demonstrating the activation of brain cells by covid-19 virus spike protein.

How the spike protein used by the coronavirus to enter human cells can have a similar effect on the brain’s immune cells is described by Huddersfield researchers in the study published in the journal Molecular Neurobiology.

Their previous research discovered how the onset of Alzheimer's disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate.

COVID-19: Diet Plan and Lifestyle Modifications for the Unlock Phase
Healthy eating habits and adherence to physical activity are required during COVID-19 lockdown. WHO has prepared a set of general tips that you could follow during the lockdown to stay fit and healthy.

‘The activation of brain cells by COVID-19 virus spike protein resulted in the increased release of various inflammatory markers, which are hallmarks of neuroinflammation.’

Following this hypothesis, researchers are now questioning whether coronavirus affects the brain, could pose a risk for neurodegenerative disorders further down the line, like Alzheimer's or Parkinson's.

Oher research demonstrated the mechanism of why the virus was able to gain access into the brain through the nose, but this was the first to demonstrate how the coronavirus activated the brain's immune response.

The COVID-19 virus may not be multiplying in the brain, but when it gets into the brain, it can induce immune responses and this explains some of the trends people have reported when they have been infected such as continued brain fog and memory loss.

Post-COVID Syndrome
Post-COVID complications are the conditions that develop weeks after recovering from COVID-19

In this study, they investigated the effects of the SARS‐CoV‐2 spike protein S1 stimulation on neuroinflammation in brain nerve cells.

Results of the experiment show that the recombinant SARS-CoV-2 spike protein sub-unit S1 activated BV-2 microglia as demonstrated by an increase in the protein expression of Iba-1, which is mainly expressed by the microglia and increased by the activation of these cells.

Post-COVID-19 Food Habits for Quick Recovery
Post-COVID-19 recovery needs healthy foods to overcome the after-effects of strong medication and the psychological trauma you went through.

Activation of neuroinflammatory processes by the spike S1 protein was further confirmed by results showing increased iNOS-mediated production of NO by the protein in brain cells.

Elevated iNOS/NO has been previously linked to a wide range of CNS disorders including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, and migraine.

COVID-19 Booster Dose Alters Taste Sensation In Mouth
The third dose of the COVID-19 vaccine (booster dose) brings about an intense metallic taste in the mouth that can last for days.

Further studies are therefore needed to elucidate the link between COVID-19–mediated hyper-inflammation and the pathogenesis of neurological symptoms that have been reported to be associated with the disease.

These results contribute to our understanding of some of the mechanisms involved in CNS pathologies of SARS-CoV-2.

Source-Medindia