Regular exercise in obese individuals lowers memory loss and cognitive impairment, preventing neurodegenerative disorders including dementia.
Exercise training improves long-term memory in obese mice
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Extended Physical Activity Resolves Obesity-Related Cognitive Impairment
Obesity is a major risk factor for cardiovascular metabolic diseases and neurodegenerative diseases such as dementia. The study states, that voluntary exercise training (VET) improves long-term memory in high-fat diet (HFD)-induced obese mice, increases hippocampal neurogenesis and the expression of the neurotrophic factor BDNF in the hippocampus, and decreases the expression of the inflammatory factor TNF, suggesting that long-term physical activity can prevent obesity-induced cognitive decline.
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.
‘Exercise training could be crucial in improving memory and cognitive function, keeping neurodegenerative disorders at bay. #exercise #memory #cognitivefunction #brainhealth’
Particularly, their results showed that VET upregulated Bdnf mRNA levels in the hippocampus of obese mice, but had no significant effect on BDNF protein levels in the hippocampus and blood, consistent with previous reports that the increase in BDNF expression in the hippocampus is transient and occurs only within a limited time window. The downregulation of TNF expression after exercise training suggests that exercise may induce a mild inflammatory stimulus in the brain, contributing to mouse memory improvement.
Reference:
- Exercise training improves long-term memory in obese mice - (https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/load043/7422812?login=false)
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