A mechanism used by tumors to recruit stem cells from bone and convert them into cancer-associated fibroblasts has been identified by researchers.
Protein Plays a Key Role in Spread of Tumor Growth
A new protein has been discovered by scientists that plays a key role in spread of tumor growth, raising hope for putting a brake in spread of cancer cells.
A new protein has been discovered by scientists that plays a key role in spread of tumor growth, raising hope for putting a brake in spread of cancer cells.
‘Biochemical pathways and cell signaling molecules used by tumors to recruit stem cells from bone and convert them into cancer-associated fibroblasts (CAFs) that facilitate tumor progression have been identified by researchers.’
The authors show that breast cancer cells use basic
fibroblast growth factor (bFGF) signaling to help them attract bone
mesenchymal stem cells (MSCs) and induce their conversion into CAFs.
They present evidence of the pro-tumor effects of stem cell recruitment
and CAFs, primarily through their effects on the tumor microenvironment. "Here we have for the first time a mechanistic underpinning of how a tumor might recruit MSCs and induce their conversion to cancer-associated fibroblasts which then facilitate tumor progression," says Editor-in-Chief Graham C. Parker, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. "The crucial role of bFGF signaling provides not only a greater understanding of the process, but also suggests therapeutic targets."
Source-Eurekalert
Key Protein That May Prevent Colon Inflammation and Tumor Growth Identified
The role of an important protein in the regulatory pathway that is involved in limiting colon inflammation and tumor growth has been discovered by researchers.
The role of an important protein in the regulatory pathway that is involved in limiting colon inflammation and tumor growth has been discovered by researchers.
Unraveling Tumor Growth in Stem Cells
At the University of Cambridge, researchers have discovered that a single mutation in a leukemia-associated gene reduces the ability of blood stem cells to make more blood stem cells, but leaves their progeny daughter cells unaffected.
At the University of Cambridge, researchers have discovered that a single mutation in a leukemia-associated gene reduces the ability of blood stem cells to make more blood stem cells, but leaves their progeny daughter cells unaffected.
Tumor Growth in Mice Slowed Down Through Injection of Human Stem Cells
A new study published in the journal Stem Cell Research & Therapy found that tumor growth in mice could be slowed down by injecting human stem cells into the mice.
A new study published in the journal Stem Cell Research & Therapy found that tumor growth in mice could be slowed down by injecting human stem cells into the mice.
