Most of the patients with advanced chronic kidney disease have poor thyroid function. Impaired thyroid function was found to affect the well-being of dialysis patients.
In dialysis patients, impaired thyroid function may have detrimental effects on the health and well-being, finds a new study. Although hypothyroidism -- a condition in which the thyroid gland does not produce enough thyroid hormone -- is common in hemodialysis patients, it's unclear how it affects their health and quality of life.
‘In hemodialysis patients, impaired thyroid function affected the quality of life including fatigue, physical function, and pain.’
To investigate, Connie M. Rhee, MD, MSc (University of California Irvine) and her colleagues examined information from 450 hemodialysis patients from 17 outpatient dialysis facilities who completed questionnaires every 6 months. To assess thyroid function, the team measured patients' blood levels of thyrotropin, which is elevated in patients with hypothyroidism.Higher thyrotropin levels were associated with impairments across multiple areas of health-related quality of life, including energy/fatigue, physical function, and pain.
"Given the high prevalence of thyroid dysfunction and low levels of quality of life in dialysis patients, future research is needed to determine the underlying mechanisms of these associations, and whether thyroid hormone replacement can improve the health-related quality of life of this population," said Dr. Rhee.
"In addition, as the first study in dialysis patients to document an association between higher thyrotropin levels and low levels of physical function, a strong predictor of death, future studies are needed to determine whether correction of thyroid status with exogenous thyroid hormone can improve physical function in this population."
The findings of the study are published in the Clinical Journal of the American Society of Nephrology (CJASN).
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