Intravenous Thrombolysis (IVT) pretreatment may improve mechanical thrombectomy (MT) outcomes in emergent large-vessel occlusions (ELVO) patients

‘At three months post-therapy, the combined therapy group did not differ significantly in terms of rates of successful recanalization and rates of symptomatic intracranial hemorrhage.’

"The medical field is becoming more aware of the benefits of mechanical thrombectomy for ELVO strokes, and these new findings related to IVT pre-treatment could lead to more positive health outcomes for patients, which is the ultimate goal of our work", said Dr. Muhammad Ishfaq, lead author of the study and resident physician at the University of Tennessee Health Science Center.




The observational study collected data from 6 high-volume endovascular stroke centers over a two-year period. A total of 292 patients underwent IVT & MT, while 277 patients underwent MT monotherapy. Following a propensity-matched analysis, patients in both groups were matched. However, the combined group tended to have higher rates of functional improvement (47% vs. 37%) and lower rates of mortality (18% vs. 29%). The IVT pre-treatment was independently associated with the beneficial outcomes based on the matched subgroups of patients.
Source-Eurekalert