Children exposed to maternal antenatal corticosteroid treatment have higher rates of behavioral, emotional, and psychological development disorders than nonexposed kids.
Prenatal exposure to corticosteroid treatment is associated with increased rates of mental and behavioral disorders in childhood, reports a new study. The findings of the study are published in the journal JAMA.// Maternal antenatal corticosteroid treatment is standard care when there is a risk for preterm delivery. The treatment improves the prognosis of babies born preterm.
‘Exposure to maternal antenatal corticosteroids significantly increases mental and behavioral disorders in kids. These findings may help inform decisions regarding maternal antenatal corticosteroid treatment.’
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The difference in the rates of these disorders was most evident in children born at term after maternal antenatal corticosteroid treatment exposure, as reported in the study. Of the term-born children who were exposed to this maternal treatment, 8.9% had been diagnosed with an emotional, behavioral, or psychological development disorder. Of the nonexposed term-born children, the rate was 6.3%. Read More..
In high-income countries, antenatal corticosteroid treatment has been in routine use for over 30 years. Recommendations and clinical care guidelines for maternal antenatal corticosteroid treatment differ between continents and countries. In Finland, the treatment is currently recommended when the risk for preterm delivery is at 34 gestational weeks or less. In select cases, the treatment is recommended even later in gestation. Corticosteroids accelerate fetal maturation, especially in the lungs, and increase the child's resilience to the stress that results from being born preterm.
The population-based register study used records from the Finnish Medical Birth Register and the Care Register for Health Care. The registers are kept at the THL Finnish Institute for Health and Welfare, which is the statutory statistical authority for social and healthcare data in Finland. The researchers followed up with over 670 000 singleton children born between 2006 and 2017. Of the pregnant mothers, 2.2% were treated with corticosteroids when preterm birth was imminent.
Maternal corticosteroid procedure is an effective treatment - but the long-term benefits and harms should still be weighed
The researchers emphasize that maternal corticosteroid treatment is an effective treatment and can be life-saving for babies who are born extremely or very preterm. However, in recent years, there has been considerable debate on whether to expand the treatment indications beyond 34 gestational weeks. In Finland, this treatment is recommended, for instance, in the case of elective cesarean section, until 36 gestational weeks. Gestational week 36 refers to a pregnancy that has lasted for 36 weeks and six days.
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"Of the mothers who were treated with antenatal corticosteroids, 45% went on to deliver a term baby. This means that prediction of preterm birth is often very difficult," he adds.
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The study took into account a number of factors that increase the risk of preterm birth, including maternal pregnancy disorders and smoking during pregnancy. The study also compared term-born maternal sibling pairs, of which one sibling was exposed to maternal antenatal corticosteroid treatment and the other sibling was not.
Also in these sibling comparisons, the treatment-exposed children had higher rates of emotional, behavioral and psychological development disorders, suggesting that shared genetic or familial factors do not explain these associations.
In term-born children, the findings could not be attributed to a single, specific disorder. However, in preterm children whose mothers had received corticosteroid treatment, the rate of mild intellectual disability was lower than in preterm children whose mothers had not received the treatment. This finding is in line with those showing that maternal antenatal corticosteroid treatment improves the prognosis of the children born preterm.
"Even though experimental studies in animals have shown that antenatal corticosteroid treatment has harmful effects on the neurodevelopment of the offspring, population-based cohort studies, like ours, cannot verify if any of the harmful effects on child disorders are accounted for by maternal corticosteroid treatment or if some other factor explains these associations. We tested for several candidates, but none of these factors explained the associations," says Professor Katri Raikkonen from the University of Helsinki.
Source-Eurekalert